{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:55:02Z","timestamp":1783137302314,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Continuous subcutaneous infusion of foslevodopa\/foscarbidopa (CSFLI) and intrajejunal levodopa\u2010carbidopa intestinal gel (LCIG) are established options for advanced Parkinson's disease (PD). Real\u2010world data on early titration and management are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare clinical course, safety, and practical implications of titration with CSFLI versus LCIG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study across nine Italian centers using uniform titration protocols, we analyzed 103 patients treated with CSFLI and 129 with LCIG. Clinical outcomes, levodopa equivalent daily dose (LEDD), follow\u2010up needs, and adverse events were evaluated over 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both therapies improved motor symptoms and quality of life. CSFLI required more frequent follow\u2010up visits and larger LEDD increases to reach optimization, with common but generally mild local reactions. LCIG showed fewer titration demands, with occasional peristomal issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While equally effective, CSFLI requires closer supervision during early management. Recognizing these practical differences can guide therapy selection and service planning in advanced PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70448","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T10:25:48Z","timestamp":1763720748000},"page":"1277-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Titration Dynamics and Early Treatment Burden in Advanced Parkinson's Disease: A Multicenter Comparison of CSFLI and LCIG Infusion Therapies"],"prefix":"10.1002","volume":"13","author":[{"given":"Beatrice","family":"Pinna","sequence":"first","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fenu","sequence":"additional","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mellino","sequence":"additional","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Serra","sequence":"additional","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Cadeddu","sequence":"additional","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Murgia","sequence":"additional","affiliation":[{"name":"SC Neurologia e Stroke Unit, AO G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gozzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliera\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-5334","authenticated-orcid":false,"given":"PIetro","family":"Antenucci","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliera\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tessitore","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences\u2014MRI Research Center Vanvitelli\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Ciaramaglia","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences\u2014MRI Research Center Vanvitelli\u2010FISM University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Modugno","sequence":"additional","affiliation":[{"name":"Unit of Neurology, IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pietracupa","sequence":"additional","affiliation":[{"name":"Unit of Neurology, IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol","family":"Avenali","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation National Neurological Institute  Pavia Italy"},{"name":"Department of Brain and Behavioural Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Zangaglia","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation National Neurological Institute  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Valentino","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation National Neurological Institute  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-594X","authenticated-orcid":false,"given":"Antonio","family":"Pisani","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation National Neurological Institute  Pavia Italy"},{"name":"Department of Brain and Behavioural Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-5972","authenticated-orcid":false,"given":"Marcello Mario","family":"Mascia","sequence":"additional","affiliation":[{"name":"Neurology UOC, Azienda Ospedaliero\u2010Universitaria di Cagliari  Cagliari Italy"},{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Puligheddu","sequence":"additional","affiliation":[{"name":"Neurology UOC, Azienda Ospedaliero\u2010Universitaria di Cagliari  Cagliari Italy"},{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari 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