{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:05:41Z","timestamp":1789704341838,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment\u2010emergent motor and neurocognitive adverse events (MNTs) are rare but increasingly well\u2010documented complications of chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy. Here, we describe the development of parkinsonism in four patients who received CAR\u2010T therapy with either B\u2010cell maturation antigen (BCMA)\u2010targeting ciltacabtagene autoleucel for multiple myeloma (n\u2009=\u20093) or CD\u201019\u2010targeting axicabtagene autoleucel for lymphoma (n\u2009=\u20091).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>We report four cases of parkinsonism in patients who received CAR\u2010T therapy. Two patients had evidence of underlying neurodegenerative parkinsonism, either clinically or through subsequent workup for their movement disorder. All patients received some combination of symptom\u2010directed and immunomodulatory therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This report describes features of CAR\u2010T treatment\u2010emergent parkinsonism, introduces parkinsonism as a potential effect of CD\u201019\u2010targeted CAR\u2010T therapy, and suggests utility of screening for underlying clinical or biomarker signs of pre\u2010existing neurodegenerative parkinsonism prior to CAR\u2010T infusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70452","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:10:11Z","timestamp":1763547011000},"page":"1539-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment\u2010Emergent Parkinsonism in Four Patients Treated with Chimeric Antigen Receptor T\u2010Cell Therapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-2540","authenticated-orcid":false,"given":"John B.","family":"Sanderson","sequence":"first","affiliation":[{"name":"University of Washington Department of Neurology  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Han","family":"Lin","sequence":"additional","affiliation":[{"name":"University of Washington Department of Neurology  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmy","family":"Su","sequence":"additional","affiliation":[{"name":"University of Washington Department of Neurology  Seattle WA USA"},{"name":"Department of Neurology Veteran Affairs Puget Sound Health Care System  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Washington Department of Neurology  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Portuguese","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Department of Internal Medicine  Seattle WA USA"},{"name":"Fred Hutchinson Cancer Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Department of Internal Medicine  Seattle WA USA"},{"name":"Fred Hutchinson Cancer Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Durbin","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Department of Internal Medicine  Seattle WA USA"},{"name":"Fred Hutchinson Cancer Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Department of Internal Medicine  Seattle WA USA"},{"name":"Fred Hutchinson Cancer Center  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41408-022-00629-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JTCT.2025.01.313"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_SUPPL.7522"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2024025945"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2023021429"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2023020571"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591-021-01564-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDC3.14239"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDC3.14335"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2023021860"}],"container-title":["Movement 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Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:24:08Z","timestamp":1789701848000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mdc3.70452"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70452","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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