{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:49:55Z","timestamp":1790790595769,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale\u2010Part III (MDS\u2010UPDRS\u2010III) is subjective and insensitive to subtle changes in patients with Parkinson's disease (PD). Computer vision (CV) can extract objective kinematics from routine outpatient videos, potentially augmenting the accuracy of the motor assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We set out to (1) Identify CV\u2010derived finger\u2010tapping features that discriminate PD from healthy controls (HC); and (2) Quantify the relationship of these extracted features with clinical and Dopamine Transporter Single\u2010photon Emission Computed Tomography (DAT\u2010SPECT) anchors in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed outpatient finger\u2010tapping videos from PD patients with DAT\u2010SPECT positivity within one year from videos and HC. A Mediapipe\u2010based pipeline quantified tapping velocity, changes in amplitude, and variability in amplitude and rhythm. Diagnostic performance was estimated with Receiver Operating Characteristic Area Under the Curves (ROC AUC) and 95% Confidence Interval (CI). Spearman assessed the relationship between tapping features, MDS\u2010UPDRS\u2010III, item 3.4 (finger tapping), and disease duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two PD patients and ten controls were included. Amplitude variability (AUCs, 0.93; 95% CI, 0.84\u20130.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and rhythm variability (AUC, 0.83; 95% CI, 0.69\u20130.94,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) exhibited the best discriminatory capacity for a PD diagnosis. MDS\u2010UPDRS\u2010III correlated positively with amplitude variability (\u03c1\u2009=\u20090.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and amplitude decrement (\u03c1\u2009=\u20090.414,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009), and negatively with tapping velocity (\u03c1\u2009=\u2009\u22120.34,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05). Amplitude variability (\u03c1\u2009=\u20090.387,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014), and rhythm variability (\u03c1\u2009=\u20090.304,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.045) directly correlated with item 3.4, while amplitude variability positively correlated with disease duration (\u03c1\u2009=\u20090.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CV\u2010derived tapping variability features objectively discriminated PD from healthy subjects and tracked motor severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70488","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T09:05:43Z","timestamp":1766221543000},"page":"1266-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-8020","authenticated-orcid":false,"given":"Pasquale Maria","family":"Pecoraro","sequence":"first","affiliation":[{"name":"Operative Research Unit of Neurology, Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"},{"name":"Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6438-9911","authenticated-orcid":false,"given":"Luca","family":"Marsili","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cannavacciuolo","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Duque","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Abanto","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology Queens University  Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Scheler","sequence":"additional","affiliation":[{"name":"Department of Radiology Nuclear Medicine, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba A.","family":"Deraz","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"},{"name":"Neurology department Cairo University Hospitals  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Wingler","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Lazzaro","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Neurology, Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"},{"name":"Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-136X","authenticated-orcid":false,"given":"Alberto J.","family":"Espay","sequence":"additional","affiliation":[{"name":"James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-757X","authenticated-orcid":false,"given":"Lazzaro","family":"di Biase","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Neurology, Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"},{"name":"Brain Innovations Lab Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-0833","authenticated-orcid":false,"given":"Matteo","family":"Bologna","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed  Pozzilli Italy"},{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome 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