{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:56Z","timestamp":1789704296847,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010IAIHU\u201006"],"award-info":[{"award-number":["ANR\u201010\u2010IAIHU\u201006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep brain stimulation of the internal globus\u2010pallidus (GPi\u2010DBS) improves focal dystonia, often incompletely. GPi\u2010DBS modulates pallido\u2010thalamo\u2010cortical pathways; however, involvement of descending pathways, including the mesencephalic locomotor region (MLR), has been proposed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate structural connectivity for predicting outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 21 focal dystonia patients with GPi\u2010DBS. Dystonia was assessed pre\u2010 and postoperatively. Contacts were localized, volumes of tissue activated (VTA) modeled, and structural connectivity quantified using probabilistic tractography and each patient's VTA to filter a normative connectome from two healthy cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GPi\u2010DBS induced mean improvement of 48.2% (SD 37.4%) in TWSTRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003) and 26.7% (SD 63.4%) in BFMDRS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.068) in cervical dystonia patients. The sweet\u2010spot was within sensorimotor GPi. For the 15 cervical dystonia patients, VTA\u2010MLR connectivity positively correlated with TWSTRS improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), with no significant VTA\u2010thalamic connectivity association (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.30).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cervical dystonia improvement depends on the GPi\u2010MLR pathway, supporting tractography to optimize DBS efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70518","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:23:02Z","timestamp":1768627382000},"page":"1496-1502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Brain Stimulation of the Internal Pallidum Modulates the Mesencephalic Locomotor Pathway in Improved Cervical Dystonic Patients"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-2004","authenticated-orcid":false,"given":"Gaetan","family":"Poulen","sequence":"first","affiliation":[{"name":"Stereotactic and Functional Neurosurgery Department University Medical Center Gui de Chauliac  Montpellier France"},{"name":"Research Unit, (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux)  Montpellier 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H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vidailhet","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau\u2010Paris Brain Institute (ICM), Inserm, CNRS, APHP  Paris France"},{"name":"Neurology Department H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Coubes","sequence":"additional","affiliation":[{"name":"Stereotactic and Functional Neurosurgery Department University Medical Center Gui de Chauliac  Montpellier France"},{"name":"Research Unit, (URCMA: Unit\u00e9 de Recherche sur les Comportements et Mouvements Anormaux)  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lau","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau\u2010Paris Brain 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