{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:05:09Z","timestamp":1789704309473,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is a neurodegenerative disorder accompanied by cognitive impairment, which increases a risk of dementia as the condition progresses. Although monoamine oxidase B (MAO\u2010B) inhibitors, such as selegiline, rasagiline and safinamide, are used to treat motor symptoms in PD, their impacts on cognitive performance remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study systematically evaluated and compared the impacts of MAO\u2010B inhibitors on global cognitive performance and performance of individual cognitive domains in patients with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases were searched through PubMed\/Medline, Embase, and Cochrane Library from the inception to May 30, 2025. Thirteen randomized controlled trials (RCTs) evaluating cognitive outcomes in patients with PD treated with selegiline, rasagiline or safinamide were included. Standardized mean differences (SMDs) for global cognition and five cognitive sub\u2010domains were pooled, respectively, using random\u2010effects models. Publication bias and methodological quality were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>13 RCTs met inclusion criteria. Network meta\u2010analysis showed that only rasagiline significantly improved global cognition compared to placebo (SMD, 0.863; 95% CI, 0.064\u20131.663), whereas selegiline and safinamide did not show any statistical difference when compared to placebo. None of the MAO\u2010B inhibitors demonstrated significant effects on specific cognitive sub\u2010domains (ie, attention, executive function, memory, language, and visuospatial abilities).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rasagiline may provide global cognitive benefits in PD, but MAO\u2010B inhibitors, including rasagiline, generally did not demonstrate significant effects on individual cognitive domains. These findings suggest limited cognitive impacts of MAO\u2010B inhibitors beyond managing the motor symptoms. Further large\u2010scale, long\u2010term studies using domain\u2010specific cognitive assessments are warranted to clarify their roles in cognitive performance in patients with PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70520","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T11:08:09Z","timestamp":1768216089000},"page":"1468-1478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <scp>MAO<\/scp>\n                    \u2010B Inhibitors on Cognition in Patients with Parkinson's Disease: A Systematic Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Seon\u2010Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Konyang University College of Medicine  Daejeon Republic of Korea"},{"name":"Myunggok Medical Research Institute Konyang University College of Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ryul","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Konyang University College of Medicine  Daejeon Republic of Korea"},{"name":"Evidence Based Research Center Konyang University Hospital  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeho Greg","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Public Health Sciences University of Connecticut School of Medicine  Farmington Connecticut 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