{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:05:01Z","timestamp":1789704301949,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Assessment of disease progression in Parkinson's disease (PD) usually relies on longitudinal follow\u2010up, which is often impractical in large real\u2010world cohorts. Cross\u2010sectional approaches may provide pragmatic proxies to explore relative motor deterioration using routine clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore clinical and non\u2010motor correlates of estimated relative motor progression in PD using a simple ratio\u2010based index\u2014MDS\u2010UPDRS Part III (OFF medication) divided by disease duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cross\u2010sectional study, 711 patients with idiopathic PD were classified as slow or fast progressors based on the cohort median of the MDS\u2010UPDRS III (OFF)\/disease duration ratio (7.31 points\/year). Motor, non\u2010motor, demographic, and treatment\u2010related variables were compared between groups. Multivariable logistic regression analyses were used to identify clinical features associated with higher estimated progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with higher estimated motor burden per year showed greater non\u2010motor symptom burden, higher residual motor load (ON\/OFF ratio), and a higher prevalence of the akinetic\u2010rigid phenotype. In multivariable analyses, non\u2010motor symptom burden, residual motor ratio, shorter disease duration, and akinetic\u2010rigid phenotype were independently associated with higher estimated progression. Among non\u2010motor domains, Sleep\/Fatigue and Miscellaneous symptoms showed specific associations. The models demonstrated good within\u2010cohort explanatory performance (Nagelkerke\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.42\u20130.47) in this cross\u2010sectional cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents a simple ratio\u2010based proxy to explore relative motor progression in PD. While not a validated longitudinal progression measure, it may serve as a pragmatic exploratory tool for descriptive stratification of large clinical cohorts. Longitudinal validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70528","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:28:41Z","timestamp":1768256921000},"page":"1479-1487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Correlates of a Ratio\u2010Based Progression Index in Parkinson's Disease: Insights from a Large Cross\u2010Sectional Cohort"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-2278","authenticated-orcid":false,"given":"Halil","family":"Onder","sequence":"first","affiliation":[{"name":"Department of Neurology Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismet","family":"Melek","sequence":"additional","affiliation":[{"name":"Department of Neurology Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-0653","authenticated-orcid":false,"given":"Rifat","family":"Bozkus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Comoglu","sequence":"additional","affiliation":[{"name":"Department of Neurology Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"issue":"6","key":"e_1_2_10_4_1","first-page":"535","article-title":"Progression of MDS\u2010UPDRS scores over five years in De novo Parkinson's disease","volume":"5","author":"Holden 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