{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:41Z","timestamp":1789704281189,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Dopaminergic neuron loss in the substantia nigra, particularly the nigrosomes, characterizes Parkinson's disease (PD). Nigrosome\u20101 absence on MRI has emerged as a potential PD biomarker.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n Assess the diagnostic accuracy of nigrosome\u20101 detection for differentiating PD from essential tremor (ET) in clinical practice.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Movement disorder neurologists without nigrosome evaluation experience, randomized into receiving or not training, assessed 3 Tesla MRIs from PD and ET patients. PD was defined by absence of at least one nigrosome. Diagnostic accuracy measures and inter\u2010rater agreement were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventy\u2010two MRIs were included (43 PD, 29 ET). Mean sensitivity, specificity, and accuracy were 78.2% (95% confidence interval: 71.2\u201385.3), 56.7% (50.0\u201364.0), 69.5% (65.3\u201373.9), without significant differences between groups. Specificity (\n P<\/jats:italic>\n \u2009=\u20090.002) and accuracy (\n P<\/jats:italic>\n \u2009=\u20090.029) increased with rating experience.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Nigrosome assessment in routine MRI by inexperienced raters showed limited diagnostic performance, yet may improve with optimized protocols and continued practice.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70530","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:39:09Z","timestamp":1768815549000},"page":"1508-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI<\/scp>\n Assessment of Nigrosome in Parkinson's Disease: Is it Currently a Valuable Tool in Clinical Practice?"],"prefix":"10.1002","volume":"13","author":[{"given":"Agustina","family":"Ruiz Yanzi","sequence":"first","affiliation":[{"name":"Centro Integral de Neurociencias AC (CINAC) HM Universitario Puerta del Sur Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"},{"name":"PhD Neurosciences Program Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c1.","family":"Pineda\u2010Pardo","sequence":"additional","affiliation":[{"name":"Centro Integral de Neurociencias AC (CINAC) HM Universitario Puerta del Sur Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-5005","authenticated-orcid":false,"given":"Elena","family":"Natera\u2010Villalba","sequence":"additional","affiliation":[{"name":"Centro Integral de Neurociencias AC (CINAC) HM Universitario Puerta del Sur Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"},{"name":"PhD Medicine Program Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Obeso","sequence":"additional","affiliation":[{"name":"Centro Integral de Neurociencias AC (CINAC) HM Universitario Puerta del Sur Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"},{"name":"CIBERNED, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-8667","authenticated-orcid":false,"given":"Michele","family":"Matarazzo","sequence":"additional","affiliation":[{"name":"Centro Integral de Neurociencias AC (CINAC) HM Universitario Puerta del Sur Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales Madrid Spain"},{"name":"CIBERNED, Instituto de Salud Carlos III Madrid 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