{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:49:04Z","timestamp":1790948944161,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Impulse control disorders (ICDs) are most often associated with dopamine agonists and pulsatile dopamine replacement therapy such as oral levodopa and subcutaneous apomorphine. Intestinal levodopa\u2013carbidopa gel may improve ICDs through rationalization of dopaminergic agents and\/or a reduction of pulsatile dopaminergic stimulation, however the impact of subcutaneous foslevodopa\/foscarbidopa (CSFLI) has not been reported to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>We describe five men aged 50\u201368 with advanced Parkinson's disease (PD) and pre\u2010existing ICDs who were switched to CSFLI. Four of them were transitioned directly from subcutaneous apomorphine infusions with the hope of improving ICD symptoms. All experienced worsening or persistent ICD symptoms, predominantly hypersexuality, after switching to CSFLI with a mean time to peak ICD symptoms of 4.5\u2009weeks (range 2\u20136).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CSFLI may exacerbate ICDs in susceptible individuals. Pre\u2010treatment screening and close monitoring are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70533","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:27:01Z","timestamp":1768382821000},"page":"1301-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Persisting or Worsening Impulse Control Disorders in Parkinson's Disease Following a Switch to Subcutaneous Foslevodopa\u2010Foscarbidopa"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-4810","authenticated-orcid":false,"given":"Maeve","family":"Bradley","sequence":"first","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"},{"name":"School of Medicine, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-0943","authenticated-orcid":false,"given":"Eoghan","family":"Donlon","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"},{"name":"School of Medicine, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"},{"name":"School of Medicine, University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Inocentes","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Diaz","family":"Rua","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"O\u2019Keeffe","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Lynch","sequence":"additional","affiliation":[{"name":"Dublin Neurological Institute at the Mater Misercordiae University Hospital  Dublin Ireland"},{"name":"School of Medicine, University College Dublin  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Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23501"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.70240"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30239-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8803-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00400-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12865-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.08.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2023.100212"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22164"}],"container-title":["Movement 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