{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:57:38Z","timestamp":1784602658690,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. \u03b1\u2010synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals. As preventive strategies remain unavailable, it is important to understand at\u2010risk individuals\u2019 attitudes toward disclosure of genetic and biomarker information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine awareness, emotional responses, and behavioral intentions among first\u2010degree relatives of PD patients who underwent genetic testing and counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional questionnaire was administered to first\u2010degree relatives tested and counseled at Tel Aviv Sourasky Medical Center. The survey assessed recall of testing and results, adequacy of information, emotional reactions, willingness to undergo biological testing (blood vs. lumbar puncture), and readiness to modify lifestyle following positive biomarker results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 240 non\u2010manifesting relatives (NMNC\u2009=\u2009145; LRRK2\u2009=\u200940; GBA1\u2009=\u200949; dual\u2009=\u20096; 72% response), the mean interval from testing to survey was 5.3\u2009\u00b1\u20092.4\u2009years. Despite prior counseling, only 70.3% recalled being tested and 66.5% remembered results. About half felt adequately informed about PD (50.9%) and their genetic status (53.7%). Willingness for blood testing was high (86.6%) but lower for lumbar puncture (41.5%). Mutation carriers reported greater distress, while 87.6% indicated readiness to adopt lifestyle changes if results were positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>First\u2010degree relatives favored minimally invasive testing and showed strong motivation for lifestyle adaptation. Limited recall of results highlights the need for improved communication and ongoing counseling in preventive neurology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70535","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:40:36Z","timestamp":1768819236000},"page":"1681-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic and Pathological Testing Attitudes for Parkinson's Disease in At\u2010Risk Relatives"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1964-4503","authenticated-orcid":false,"given":"Tal","family":"Weil","sequence":"first","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Mirelman","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Sagol School of Neuroscience Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Laboratory of Early Markers of Neurodegeneration Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy N.","family":"Alcalay","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Sagol School of Neuroscience Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Movement Disorders Unit Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Department of Neurology Columbia University Irving Medical Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurit","family":"Omer","sequence":"additional","affiliation":[{"name":"Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Laboratory of Early Markers of Neurodegeneration Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Movement Disorders Unit Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penina","family":"Ponger","sequence":"additional","affiliation":[{"name":"Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Movement Disorders Unit Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avner","family":"Thaler","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Sagol School of Neuroscience Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Laboratory of Early Markers of Neurodegeneration Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"},{"name":"Movement Disorders Unit Neurological Institute, Tel\u2010Aviv Medical Center  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080952"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldad035"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27362"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3902"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.314"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01282-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00405-2"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"1","article-title":"SynNeurGe research diagnostic criteria for Parkinson's disease","volume":"39","author":"Berg D","year":"2024","journal-title":"Mov Disord"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.24"},{"issue":"10","key":"e_1_2_11_13_1","first-page":"1725","article-title":"A statement of the MDS on biological definition, staging, and classification of Parkinson's disease","volume":"38","author":"Cardoso F","year":"2023","journal-title":"Mov Disord"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30141"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.971252"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.10.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24781"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13081212"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1877718X241310722"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01259-1"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70117-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"issue":"10","key":"e_1_2_11_23_1","first-page":"1190","article-title":"Disclosing genetic risk information for Alzheimer disease to adults with mild cognitive impairment","volume":"75","author":"Christensen KD","year":"2018","journal-title":"JAMA Neurol"},{"key":"e_1_2_11_24_1","volume-title":"Research Methods in Health: Investigating Health and Health Services","author":"Bowling A","year":"2014"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800389"},{"issue":"2","key":"e_1_2_11_26_1","first-page":"243","article-title":"CAP sleep dynamics in at\u2010risk PD individuals","volume":"97","author":"Dagay A","year":"2025","journal-title":"Ann Neurol"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209201"},{"issue":"3","key":"e_1_2_11_28_1","first-page":"300","article-title":"Informing Alzheimer's biomarker communication: concerns and understanding of cognitively unimpaired adults during amyloid results disclosure","volume":"11","author":"Ketchum FB","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"issue":"1","key":"e_1_2_11_29_1","first-page":"189","article-title":"Antidiabetic medication and risk of Parkinson disease","volume":"11","author":"Lin CH","year":"2021","journal-title":"J Parkinsons Dis"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29122"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae142"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00569-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1325231"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000206891"},{"issue":"24","key":"e_1_2_11_35_1","first-page":"e2913","article-title":"Psychological impact of disclosure of amyloid PET results: implications for Alzheimer's clinical trials","volume":"96","author":"Roberts JS","year":"2021","journal-title":"Neurology"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2734"},{"key":"e_1_2_11_37_1","article-title":"Resilience and psychological distress in genetic testing for Alzheimer's disease","author":"Burgei A","year":"2024","journal-title":"Grad Stud J Psychol"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00645-4"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08076-z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.107256"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:13:15Z","timestamp":1784293995000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mdc3.70535"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70535","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}