{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:56Z","timestamp":1789704296912,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fever and worsening rigidity in Parkinson's disease (PD) may resemble neuroleptic malignant syndrome (NMS). We examined PD patients diagnosed with NMS\u2014regardless of whether diagnostic criteria were used\u2014to establish the clinical characteristics and etiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>Among 15 cases, 40% (6\/15) required ICU admission, 27% (4\/15) required mechanical ventilation, 80% (12\/15) recovered, and 20% (3\/15) died. 27% (4\/15) had a reduction in carbidopa\u2010levodopa as the primary trigger, 27% (4\/15) had sepsis in addition to concurrent reductions in carbidopa\u2010levodopa, 7% (1\/15) had sepsis alone, 33% (5\/15) were exposed to new or increased antidopaminergic drugs, and 7% (1\/15) had deep brain stimulator (DBS) malfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Review<\/jats:title>\n                    <jats:p>Several terms to describe exacerbation of parkinsonism including NMS\u2010like state and parkinsonism hyperpyrexia syndrome (PHS) have been proposed over the years but may be restrictive in their definitions and confounders exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute parkinsonism dopamine depletion syndrome (APDDS) might be a more encompassing term to describe to an acute exacerbation of preexisting parkinsonism resulting from recent reduction in dopaminergic or other Parkinson's therapy (eg, DBS failure), or exposure to antidopaminergics. Symptoms include increased rigidity, encephalopathy, hyperthermia, or autonomic instability. Sepsis is a frequent confounder and may be associated with concurrent reduction or discontinuation of carbidopa\u2010levodopa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70536","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:20:38Z","timestamp":1768558838000},"page":"1528-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parkinsonism Exacerbation due to Acute Dopamine Depletion: A Conundrum Revisited"],"prefix":"10.1002","volume":"13","author":[{"given":"Brett","family":"Sterk","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Psychology and Psychiatry Mayo Clinic Rochester  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco F.M.","family":"Wijdicks","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360190098033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400040130031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1991.184"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1041226"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-008-9125-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227216"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2948323"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000330"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2022.09.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0514"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257129"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2404606"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13215"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:24:38Z","timestamp":1789701878000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mdc3.70536"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70536","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}