{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:26:02Z","timestamp":1786785962816,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The nigrosome\u20101 (N1) sign on susceptibility\u2010weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni\u2212\/bilaterally preserved N1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010eight PD and 35 HC underwent 3\u2009T\u2010MR\u2010SWI. The N1 was visually assessed, and visible N1 were segmented to calculate volume, area and susceptibility values. These metrics were investigated for distinguishing between visible nigrosomes\u20101 of PD patients and HC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among PD patients, 16 had bilateral N1 loss and 32 had unilaterally (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) or bilaterally (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) preserved N1. The visible N1 were significantly smaller in PD than in HC (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), while having similar susceptibility values (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.251). N1 area and volume showed high performance (AUC: 0.97\u20130.98) in distinguishing PD from HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The measurement of volume and area of N1 region may complement visual assessment on SWI to optimize diagnostic performance in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70547","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:25:53Z","timestamp":1770121553000},"page":"1951-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Assessment of Visible Nigrosome\u20101 in Patients with Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-5552","authenticated-orcid":false,"given":"Maria Eugenia","family":"Caligiuri","sequence":"first","affiliation":[{"name":"Neuroscience Research Center Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Chimento","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marida","family":"De Maria","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Biondetti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Imaging, and Clinical Sciences University \u201cG. 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