{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:03:25Z","timestamp":1790071405724,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006209","name":"Radboud Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinocerebellar ataxia (SCA) is a rare, genetic neurodegenerative movement disorder primarily affecting the cerebellum. So far, there is no available cure for SCA. However, evidence suggests that neurorehabilitation can alleviate symptoms. The most optimal training protocol has not been established and mechanisms that channel the effects of these interventions are incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the disease\u2010specific effects of a gait adaptability training in a SCA cohort compared to healthy controls and explores underlying cerebral mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 20 early\u2010stage SCA patients and 18 matched healthy controls. A 5\u2010week, C\u2010Mill gait adaptability training protocol was conducted with 10 sessions of 1\u2009h. We evaluated the effects of training on ataxia severity, spatiotemporal gait variables, and functional mobility tests. To identify training\u2010related structural brain changes, two T1w structural MRI scans were acquired within one week before and one week after training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following training, the ataxia severity scores did not change, and measures specific to ataxia, such as stride length variability and step width, were unaffected. However, both patients and controls showed improvement in velocity, functional mobility task duration and stride and step length. These behavioral training effects were not accompanied by detectable structural gray matter changes in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that early\u2010stage SCA patients retain the ability to adapt and improve general gait performance when exposed to gait adaptability training, even though ataxia\u2010specific gait measures remain unchanged. The neural substrate mediating this training\u2010induced improvement remains unknown and needs further work.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70585","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:23:37Z","timestamp":1773768217000},"page":"2134-2144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gait Adaptability Training Improves Gait in Spinocerebellar Ataxia Patients"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3231-7984","authenticated-orcid":false,"given":"Colette J.M.","family":"Reniers","sequence":"first","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Huisman\u2010Venrooij","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Toni","sequence":"additional","affiliation":[{"name":"Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Weerdesteyn","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.C.","family":"van de Warrenburg","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000362"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-009-0144-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0074-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9076-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070134"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c33adf"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09938-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27130"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.01.021"},{"issue":"1","key":"e_1_2_13_11_1","first-page":"525879","article-title":"Effect of long\u2010term climbing training on cerebellar ataxia: a case series","volume":"2011","author":"Stephan MA","year":"2011","journal-title":"Rehabil Res Pract"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7087-8"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22740"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-019-01091-9"},{"key":"e_1_2_13_15_1","first-page":"135","volume-title":"Handbook of Clinical Neurology","author":"Weerdesteyn V","year":"2018"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.04.190"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-1180"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2021.10.010"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.028"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.021"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.03.017"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3381-12.2013"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0426"},{"key":"e_1_2_13_24_1","unstructured":"RoerdinkM BeekPJ.Device for displaying target indications for foot movements to persons with a walking disorder. 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