{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:03:37Z","timestamp":1790071417330,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT173307"],"award-info":[{"award-number":["PJT173307"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Congenital Mirror Movement Syndrome (CMMS) involves involuntary movements on one side of the body while voluntary movements are performed on the other side. They disrupt left\u2013right coordination and can be caused by a pathogenic variant in the\n                      <jats:italic>DCC<\/jats:italic>\n                      gene. CMMS have been extensively studied in the upper limb, but its impact on lower limb during gait in humans is unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Determine the impact of CMMS on locomotor patterns in individuals with a\n                      <jats:italic>DCC<\/jats:italic>\n                      pathogenic variant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The gait pattern of seven individuals with a\n                      <jats:italic>DCC<\/jats:italic>\n                      pathogenic variant and ten healthy controls was assessed using 3D motion capture (kinematics), electromyographic recordings (EMG) of the soleus (SOL) and tibialis anterior (TA) muscles and foot pressure distribution during comfortable walking, fast walking, and running.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In comparison to controls, the\n                      <jats:italic>DCC<\/jats:italic>\n                      group exhibited prolonged soleus (SOL) EMG activity and overlapping left\u2013right SOL activation at a comfortable walking speed. No change was noted in TA. Both groups demonstrated increased pressure at the toe during the push\u2010off phase; however, individuals with the most severe CMMS also displayed an early stance\u2010phase pressure peak, reflecting contralateral push\u2010off. These features diminished at higher walking speeds. Kinematic analysis revealed delayed knee flexion and prolonged double\u2010limb support in the\n                      <jats:italic>DCC<\/jats:italic>\n                      group. Group differences were more pronounced when comparing control participants to\n                      <jats:italic>DCC<\/jats:italic>\n                      individuals with observable CMMS (Wood and Tauber scale).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>DCC<\/jats:italic>\n                      variants impair left\u2013right coordination, particularly affecting distal extensor muscle timing during gait. These disruptions are most evident during slow walking and correlate with mirror movement severity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70601","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:10:46Z","timestamp":1775805046000},"page":"2154-2165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gait Alterations Due to\n                    <scp>\n                      <i>DCC<\/i>\n                    <\/scp>\n                    Gene Variants in Individuals with Congenital Mirror Movements"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7390-7509","authenticated-orcid":false,"given":"Nok\u2010Yeung","family":"Law","sequence":"first","affiliation":[{"name":"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR)  Montreal Qc Canada"},{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"},{"name":"School of Rehabilitation, Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanie","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR)  Montreal Qc Canada"},{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinthiya","family":"Sivanesan","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR)  Montreal Qc Canada"},{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"},{"name":"Universit\u00e9 Sorbonne  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Tonkov","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR)  Montreal Qc Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Charron","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM)  Montreal QC Canada"},{"name":"Department of Medicine University of Montreal  Montreal QC Canada"},{"name":"Department of Anatomy and Cell Biology, Division of Experimental Medicine McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bretzner","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec, CHUL\u2010Neurosciences  Qu\u00e9bec QC Canada"},{"name":"Faculty of Medicine, Department of Psychiatry and Neuroscience Universit\u00e9 Laval  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-0508","authenticated-orcid":false,"given":"Myriam","family":"Srour","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montreal QC Canada"},{"name":"Department of Pediatrics, Division of Pediatric Neurology McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-8364","authenticated-orcid":false,"given":"Dorothy","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR)  Montreal Qc Canada"},{"name":"Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"},{"name":"School of Rehabilitation, Universit\u00e9 de Montr\u00e9al  Montreal Qc Canada"},{"name":"CIUSSS NIM, HSCM  Montreal Qc Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1186463"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03766.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20736"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21825"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22749"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00470360097009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.7.1217"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.35.7.1059"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b59bda"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95442"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29669"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add5501"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7505-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.03.017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1889"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24549"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0216-18.2021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00075"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0028-3932(97)00107-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3758\/bf03334122"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1050-6411(00)00027-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2019311"},{"key":"e_1_2_9_25_1","volume-title":"Kinesiology of the Musculoskeletal System: Foundations for Rehabilitation","author":"Neumann DA","year":"2010"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.043331"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154775"},{"key":"e_1_2_9_28_1","unstructured":"Motion V. Systems Plug In Gait Reference Guide [Online];2021. [cited Aug 16 2023] Available from:https:\/\/help.vicon.com\/space\/Nexus217\/350752355\/Full+body+modeling+with+Plug-in+Gait#Marker-sets-for-Plug-in-Gait-full-body-modeling."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00230.2022"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01073.2004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00419.2015"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00236.2014"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197907000-00005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00081.2006"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200205000-00009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2018.09.011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03654794"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101453"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13102"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158267"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2005.09.006"},{"key":"e_1_2_9_42_1","volume-title":"Gait Analysis: an Introduction","author":"Whittle MW","year":"2007"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70601","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:06Z","timestamp":1790068686000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mdc3.70601"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70601","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}