{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:04:20Z","timestamp":1790071460357,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Primary orthostatic tremor (\n                      <jats:styled-content style=\"fixed-case\">POT<\/jats:styled-content>\n                      ) is a rare hyperkinetic movement disorder with limited and largely ineffective treatment options. Perampanel has been suggested as a therapy, but has so far only been investigated in small studies with short duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To (1) describe longitudinal perampanel use and its association with key clinical outcomes and baseline characteristics in a well\u2010defined cohort of POT, and (2) evaluate factors possibly associated with treatment continuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational cohort study in POT patients who started perampanel treatment between November 2018 and November 2022, and who completed five self\u2010report scales prior to treatment start and during clinical follow\u2010up were included. Scales assessed daily functioning and well\u2010being, and included the Dutch OT\u2010questionnaire, Hospital Anxiety and Depression Scale, (instrumental) Activities of Daily Living, and the Short Form\u201036.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty one POT patients were included, and followed for 32\u2009months on average. Seventeen patients continued taking perampanel, demonstrating improvements in social functioning, fewer emotional role limitations, better mental health, and reduced pain compared to those who discontinued. Fourteen patients discontinued perampanel due to lack of effect and\/or adverse effects, which were also common and persistent in those who continued. Men were more likely to continue treatment. Patients who discontinued had lower baseline functioning and well\u2010being scores than those continuing, which persisted over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In around half of patients, continued use of perampanel is associated with better clinical outcomes, also on the long term, but adverse effects are common and persistent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70605","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:54:28Z","timestamp":1774518868000},"page":"2145-2153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Continuation and Long\u2010Term Outcomes of Perampanel in Primary Orthostatic Tremor; A Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7532-5320","authenticated-orcid":false,"given":"Wietske A.","family":"Babeliowsky","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Swinnen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Department of Neurology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-6052","authenticated-orcid":false,"given":"Jeroen","family":"Hoogland","sequence":"additional","affiliation":[{"name":"Department Epidemiology and Data Science, Amsterdam UMC University of Amsterdam  Amsterdam the 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