{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:04:52Z","timestamp":1790071492403,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","award":["Nos.22\u201026,25\u20107"],"award-info":[{"award-number":["Nos.22\u201026,25\u20107"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek109652"],"award-info":[{"award-number":["JP23ek109652"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23lk0201124"],"award-info":[{"award-number":["23lk0201124"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625104"],"award-info":[{"award-number":["JP24wm0625104"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017090","name":"Sony","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Olfactory impairment is a key prodromal symptom of Parkinson's disease (PD), yet conventional Japanese olfactory tests require controlled rooms and time\u2010consuming manual procedures, restricting large\u2010scale use. The Next\u2010gen Olfactometry System (NOS) provides rapid, semi\u2010automated assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluate the clinical utility of the NOS as an efficient screening tool for PD\u2010related olfactory dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010three patients with PD, 21 high\u2010risk individuals (\u22652 prodromal symptoms), and 20 low\u2010risk controls underwent NOS testing (recognition and detection thresholds and a composite score). Results were compared with the Odor Stick Identification Test for Japanese (OSIT\u2010J) to evaluate correlation and discriminative ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NOS recognition and detection thresholds correlated moderately with OSIT\u2010J (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.676 and\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.516, both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). NOS recognition thresholds were significantly worse in PD than in either risk group, but did not differ between risk groups. NOS detection thresholds and OSIT\u2010J scores showed a graded decline\u2014worst in PD, intermediate in high\u2010risk, and best in low\u2010risk\u2014with every pairwise contrast significant. The NOS indices may discriminate between the PD and high\u2010risk groups, as well as between the PD and low\u2010risk groups. In the exploratory analysis, NOS recognition thresholds correlated moderately with the dopamine transporter single\u2010photon\u2010emission computed tomography specific binding ratio in the high\u2010risk group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NOS indices showed moderate agreement with OSIT\u2010J. Although NOS did not surpass OSIT\u2010J in discrimination between high\u2010 and low\u2010risk individuals, its rapid, semi\u2010automated workflow makes it a practical option for large\u2010scale olfactory screening in prodromal PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70615","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:15:24Z","timestamp":1775466924000},"page":"2180-2189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Next\u2010Gen Olfactometry System for Olfactory Testing in Parkinson's Disease and High\u2010Risk Individuals"],"prefix":"10.1002","volume":"13","author":[{"given":"Taiki","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-2956","authenticated-orcid":false,"given":"Keita","family":"Hiraga","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0877-7738","authenticated-orcid":false,"given":"Daigo","family":"Tamakoshi","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya 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