{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:02:23Z","timestamp":1790071343575,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Female sex increases the risk of levodopa\u2010induced dyskinesias in Parkinson's disease (PD). While levodopa\u2010sparing effects of monoamine oxidase\u2010B inhibitors (iMAO\u2010B) are established, sex differences in response to safinamide remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate sex differences in longitudinal (9\u2009\u00b1\u20093\u2009months) changes in levodopa dose and total levodopa\u2010equivalent daily dose (LEDD) with safinamide 100\u2009mg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 259 PD patients treated with safinamide 100\u2009mg (cases, n\u2009=\u2009130) or never exposed to iMAO\u2010B (controls, n\u2009=\u2009129). The primary outcome was the sex \u00d7 treatment interaction on the change in levodopa daily dose adjusted for body weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Safinamide 100\u2009mg improved UPDRS\u2010III scores and reduced OFF\u2010time independently of sex. A significant sex \u00d7 treatment interaction emerged for change in weight\u2010adjusted levodopa dose and total LEDD, with greater reduction in women (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025 and 0.045, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Safinamide 100\u2009mg provides a larger levodopa\u2010sparing effect in women, supporting sex\u2010specific optimization of dopaminergic therapy in PD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70642","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:06:56Z","timestamp":1776834416000},"page":"2210-2215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in Levodopa\u2010Sparing Effect of Safinamide: Post\u2010hoc Findings from a Multicenter, Longitudinal, Case\u2010Control Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Roberto","family":"Cilia","sequence":"first","affiliation":[{"name":"Parkinson and Movement Disorders Unit Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-1951","authenticated-orcid":false,"given":"Emanuele","family":"Cereda","sequence":"additional","affiliation":[{"name":"Clinical Nutrition and Dietetics Unit Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Colucci","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Unit Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Piatti","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurology, Milan Center for Neuroscience, San Gerardo Hospital  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Bonvegna","sequence":"additional","affiliation":[{"name":"Centro Parkinson e Parkinsonismi, ASST Gaetano Pini\u2010CTO  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-6606","authenticated-orcid":false,"given":"Andrea","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences Department of Continuity of Care and Frailty, University of Brescia and Neurology Unit  Brescia Italy"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Center for Alzheimer Research Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-9468","authenticated-orcid":false,"given":"Cristoforo","family":"Comi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Translational Medicine Movement Disorders Centre, University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mancini","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano, IRCCS Department of Neurology Unit and Laboratory of Neuroscience  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-343X","authenticated-orcid":false,"given":"Maurizio","family":"Zibetti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cRita Levi Montalcini\u201d University of Torino  Turin Italy"},{"name":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"De Micco","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-5433","authenticated-orcid":false,"given":"Maria Chiara","family":"Sensi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria S. Anna, U.O. Neurologia  Ferrara Italy"},{"name":"University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ceravolo","sequence":"additional","affiliation":[{"name":"Unit of Neurology Department of Clinical and Experimental Medicine, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Zangaglia","sequence":"additional","affiliation":[{"name":"Parkinson's Disease and Movement Disorders Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-026X","authenticated-orcid":false,"given":"Alessio","family":"Di Fonzo","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neuroscience, Dino Ferrari Center, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pellecchia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana,\u201d Neuroscience Section University of Salerno  Fisciano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-1775","authenticated-orcid":false,"given":"Nicola","family":"Modugno","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Unit IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sorbera","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino\u2010Pulejo,\u201d  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Canesi","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, Parkinson's Disease and Movement Disorders Center Moriggia\u2010Pelascini Hospital  Gravedona 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