{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:40:13Z","timestamp":1792482013133,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016198","name":"Idorsia Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insomnia is common in restless legs syndrome (RLS), significantly impairing quality of life. Dual orexin receptor antagonists (DORAs) have demonstrated efficacy in managing insomnia and RLS symptoms. Daridorexant is a recently approved DORA for insomnia disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate the effectiveness of daridorexant 50\u2009mg\/night in treating insomnia in patients with RLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter prospective observational study included 21 patients with RLS and insomnia, evaluated at baseline and after 3\u2009months of treatment with daridorexant 50\u2009mg\/night using Insomnia Severity Index (ISI), International Restless Legs Syndrome Study Group Rating Scale (IRLS), Beck Depression Inventory\u2013II (BDI\u2010II), and a visual analogue scale for sleep quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen patients completed follow\u2010up. Significant improvements were observed at follow\u2010up in ISI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), IRLS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and BDI\u2010II scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), and sleep quality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daridorexant 50\u2009mg\/night improved insomnia, RLS, depressive symptoms, and sleep quality in RLS patients, supporting its potential use in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70651","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:00:31Z","timestamp":1777960831000},"page":"2559-2563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daridorexant Treatment for Chronic Insomnia in Restless Legs Syndrome"],"prefix":"10.1002","volume":"13","author":[{"given":"Luca","family":"Fernando","sequence":"first","affiliation":[{"name":"Neurology Unit University Hospital of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-2805","authenticated-orcid":false,"given":"Mariana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome 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IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-4938","authenticated-orcid":false,"given":"Michelangelo Maestri","family":"Tassoni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-5424","authenticated-orcid":false,"given":"Luigi","family":"Ferini\u2010Strambi","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan 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