{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:40:12Z","timestamp":1792482012597,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000324","name":"Gatsby Charitable Foundation","doi-asserted-by":"publisher","award":["GAT3676"],"award-info":[{"award-number":["GAT3676"]}],"id":[{"id":"10.13039\/501100000324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fracture risk is increased in Parkinson's yet this risk is often not addressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our objective was to study the extent to which osteoporosis was treated, and predictors of treatment in a large representative cohort with parkinsonism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The clinical practice research datalink (\n                      <jats:styled-content style=\"fixed-case\">CPRD<\/jats:styled-content>\n                      )\n                      <jats:styled-content style=\"fixed-case\">GOLD<\/jats:styled-content>\n                      data contains anonymized\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      primary care data. We identified fragility fractures (hip, vertebrae, wrist\/distal radius, humerus, rib, pelvis and unspecified osteoporotic) amongst prevalent parkinsonism patients between 2010 and 2019, and ascertained whether bone protective medications and\/or vitamin D\/calcium supplements were prescribed in the pre\u2010fracture period or in the 48\u2010weeks post\u2010fracture. Logistic regression was used to determine predictors of prescriptions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 21,581 people with parkinsonism (mean age 74.7\u2009\u00b1\u20099.8\u2009years, 40% female), with a mean of 3.1\u2009\u00b1\u20092.5\u2009years of available data. One thousand eight hundred twenty\u2010three experienced at least one fragility fracture. Prior to a fragility fracture 12% had a prescription for bone protective medication. This increased to 38% and 53% in the 16 and 48\u2010weeks post\u2010fracture, respectively. 24% already had a prescription for vitamin D\/calcium which increased to 73% at 48\u2010weeks post\u2010fracture. Female gender (OR\u2009=\u20092.06 [1.69\u20132.51],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and sustaining a vertebral fracture (OR\u2009=\u20092.06 [1.53\u20132.77],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) increased the odds of bone protection prescriptions. However, sustaining a rib fracture (OR\u2009=\u20090.34 [0.19\u20130.60],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) or residing in a care home (OR\u2009=\u20090.58 [0.38\u20130.88],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) decreased the odds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is an osteoporosis treatment gap in Parkinson's rendering an already high\u2010risk population at further risk of fracture. Men and those with rib fractures are two groups who are least likely to receive potentially beneficial treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70652","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:36:18Z","timestamp":1778470578000},"page":"2474-2499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mind the Gap: Predictors of Osteoporosis Treatment Following Fragility Fracture in Parkinsonism"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-5180","authenticated-orcid":false,"given":"Katie C.","family":"Naylor","sequence":"first","affiliation":[{"name":"Ageing and Movement Research Group, Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-1870","authenticated-orcid":false,"given":"Emily J.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Ageing and Movement Research Group, Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Older Peoples Unit Royal United Hospital NHS Foundation Trust  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-8844","authenticated-orcid":false,"given":"Emma","family":"Tenison","sequence":"additional","affiliation":[{"name":"Ageing and Movement Research Group, Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"},{"name":"Older Peoples Unit Royal United Hospital NHS Foundation Trust  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BONE.2019.115173"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/906274"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00198-013-2300-2\/TABLES\/4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00167-018-4970-Y\/TABLES\/4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INJURY.2022.03.015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25297"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01317"},{"key":"e_1_2_10_9_1","unstructured":"Parkinson's Excellence Network.Better Bone Health Service Improvement Project 1 Executive summary Background;2020."},{"key":"e_1_2_10_10_1","unstructured":"Parkinson's Excellence Network.2022 UK Parkinson's Audit\u2010Summary Report;2022."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00198-013-2438-Y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/IJE\/DYV098"},{"key":"e_1_2_10_13_1","unstructured":"CPRD.Data quality | CPRD; Accessed July 15 2025.https:\/\/www.cprd.com\/data-quality."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN-2017-019637"},{"key":"e_1_2_10_15_1","unstructured":"Royal Osteoporosis Society.Effective Secondary Prevention of Fragility Fractures: Clinical Standards for Fracture Liaison Services;2019."},{"key":"e_1_2_10_16_1","unstructured":"StataCorp.Stata Statistical Software: Release 18."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/CMAJ.190757\/-\/DC1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00198-025-07802-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFAF052"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000641"},{"key":"e_1_2_10_21_1","unstructured":"NICE.Bisphosphonates Prescribing information; Accessed January 3 2025.https:\/\/cks.nice.org.uk\/topics\/osteoporosis-prevention-of-fragility-fractures\/prescribing-information\/bisphosphonates\/."},{"key":"e_1_2_10_22_1","unstructured":"NOGG.Clinical guideline for the prevention and treatment of osteoporosis."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFAD172"},{"key":"e_1_2_10_24_1","unstructured":"Royal College of Physicians.Facing New Challenges: The National Hip Fracture Database report on 2020."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFAC044"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.05.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-017-0324-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.11.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ANNRHEUMDIS-2024-EULAR.1694"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHINTE.162.19.2217"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/EMERMED-2019-209143"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","unstructured":"WeaverJ SajjanS Michael LewieckiE HarrisST.Diagnosis and treatment of osteoporosis before and after fracture: a side\u2010by\u2010side analysis of commercially insured and Medicare advantage osteoporosis patients.2017;23(7):735\u2013744.https:\/\/doi.org\/10.18553\/JMCP.2017.23.7.735.","DOI":"10.18553\/jmcp.2017.23.7.735"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAMDA.2020.11.019"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/JGS.13550"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDC3.13146"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PARKRELDIS.2012.01.004"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00198-019-05228-8"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/BCP.14521"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PARKRELDIS.2019.03.021"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:14:35Z","timestamp":1792480475000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mdc3.70652"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70652","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2025-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}