{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:40:13Z","timestamp":1792482013078,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010028642"],"award-info":[{"award-number":["MJFF\u2010028642"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the demographic, clinical, and phenotypic profiles of a large multicenter Indian PSP cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects fulfilling MDS\u2010PSP criteria were prospectively recruited across movement disorders centers (2021\u20132025). Standardized demographic and clinical data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1035 subjects were enrolled (M:F\u2009=\u2009709:326), with a median age of 65\u2009years and a mean onset age of 62.2\u2009\u00b1\u20097.9\u2009years. Regional distribution reflected pan\u2010Indian recruitment (South 35%, North 26%, West 21%, East 18%). PSP\u2010Richardson's syndrome was most common (41%), followed by PSP\u2010Parkinsonism (18%) and PSP\u2010CBS (11%); rarer phenotypes included PSP\u2010PI (7%), PSP\u2010F (7%), PSP\u2010PGF (5%), PSP\u2010OM (2%), PSP\u2010SL (1%), and PSP\u2010C (1%). Falls occurred earliest in PSP\u2010PGF (13.7\u2009months) and PSP\u2010SL (16.3\u2009months), while PSP\u2010P showed delayed disability (falls at 31\u2009months) indicating progression patterns. Cognitive onset was prominent in PSP\u2010F (21%) and PSP\u2010SL (57%). Levodopa was prescribed to 893 patients; 186 (21%) reported &gt;25% subjective benefit, and 358 (40%) reported \u226425% benefit. Amantadine was used in 351 (34%) patients, with improvement in 177.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This largest systematically profiled PSP cohort highlights both shared and distinctive features: high frequency of non\u2010RS variants, aggressive course in PSP\u2010RS\/SL, better survival in PSP\u2010P, and limited pharmacological benefit. These findings establish a foundation for longitudinal and genetic studies in diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70672","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T02:00:14Z","timestamp":1779674414000},"page":"2439-2452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project\n                    <scp>PAIR<\/scp>\n                    \u2010\n                    <scp>PSP<\/scp>\n                    )"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-947X","authenticated-orcid":false,"given":"Prashanth Lingappa","family":"Kukkle","sequence":"first","affiliation":[{"name":"Parkinson's Disease and Movement Disorders Clinic  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3370","authenticated-orcid":false,"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-3311","authenticated-orcid":false,"given":"Jacky","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences Kolkata  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-1888","authenticated-orcid":false,"given":"Soaham","family":"Desai","sequence":"additional","affiliation":[{"name":"Shree Krishna Hospital Pramukhswami Medical College Bhaikaka University  Karamsad Anand India"},{"name":"Department of Neurology Zydus Hospital  Anand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukmini Mridula","family":"Kandadai","sequence":"additional","affiliation":[{"name":"Parkinson's disease and Movement Disorders Center Yashoda Hospitals  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pettarusp Murzban","family":"Wadia","sequence":"additional","affiliation":[{"name":"Movement Disorder Clinic, Department of Neurology Jaslok Hospital and Research Centre  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-2808","authenticated-orcid":false,"given":"Deepika","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Medical Sciences Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulup","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute of Medical Sciences and SUM Hospital  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayashankar","family":"Paramanandam","sequence":"additional","affiliation":[{"name":"Department of Neurology Apollo Hospitals  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taallapalli Ashok Vardhan","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Bibinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-3554","authenticated-orcid":false,"given":"Adreesh","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurology Bangur Institute of Neurosciences (BIN) and Institute of Post Graduate Medical Education &amp; 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