{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:23:48Z","timestamp":1791872628469,"version":"4.3.4"},"reference-count":175,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood\u2010onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic encephalopathies (DEE), however, the full spectrum of genotypes and phenotypes remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We conducted a comprehensive literature review to identify monogenic NDD and DEE disorders that are reported with hyperkinetic movement disorders\u2014specifically dystonia, chorea, and dyskinesia\u2014and analyzed the frequency of neurological, extra\u2010neurological and phenomenological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using cluster analysis, we identified data\u2010driven phenotypic groupings to inform diagnostic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 210 monogenic conditions (44.7% autosomal dominant, 45.2% autosomal recessive, 7.6% X\u2010linked), 131 (62.3%) segregated into two major clusters: one predominantly NDD and the other predominantly DEE. A variable combination of neurological, extra\u2010neurological and imaging features, as well as phenomenologies, distinguished subclusters within the NDD and DEE groups. Across both groups, dystonia was the most frequently reported movement disorder, followed in order by chorea, ataxia, dyskinesia, and myoclonus. Only a small subset of conditions expressed paroxysmal movement disorders and alternating hemiplegia of childhood, highlighting these clinical features as specific diagnostic clues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on these findings, we propose a clinical and syndromic diagnostic framework for clinicians evaluating patients with NDD, DEE, and hyperkinetic movement disorders. This approach may aid diagnosis in settings lacking access to next\u2010generation sequencing and support reverse phenotyping to improve diagnostic precision and interpretation of genomic data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70683","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:40:34Z","timestamp":1781574034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Data\u2010Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1104-4151","authenticated-orcid":false,"given":"Hugo","family":"Morales\u2010Brice\u00f1o","sequence":"first","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Westmead New South Wales Australia"},{"name":"Westmead Clinical School, Sydney Medical School, Faculty of Medicine and Health University of Sydney  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-4781","authenticated-orcid":false,"given":"Shekeeb S.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Kids Neuroscience Centre The Children's Hospital at Westmead  Westmead New South Wales Australia"},{"name":"The Children's Hospital at Westmead Clinical School, Sydney Medical School, Faculty of Medicine and Health University of Sydney  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwar Reddy","family":"Angiti","sequence":"additional","affiliation":[{"name":"Grace Centre for Newborn Intensive Care The Children's Hospital at Westmead  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velda","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Paediatric Neurology, Department of Paediatrics, Khoo Teck Puat\u2010National University Children's Medical Institute National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Tchan","sequence":"additional","affiliation":[{"name":"Westmead Clinical School, Sydney Medical School, Faculty of Medicine and Health University of Sydney  Westmead New South Wales Australia"},{"name":"Genetic Medicine Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Dale","sequence":"additional","affiliation":[{"name":"Kids Neuroscience Centre The Children's Hospital at Westmead  Westmead New South Wales Australia"},{"name":"The Children's Hospital at Westmead Clinical School, Sydney Medical School, Faculty of Medicine and Health University of Sydney  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-2282","authenticated-orcid":false,"given":"Victor S.C.","family":"Fung","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Westmead New South Wales Australia"},{"name":"Westmead Clinical School, Sydney Medical School, Faculty of Medicine and Health University of Sydney  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"19","key":"e_1_2_10_2_1","first-page":"e1884","article-title":"Movement disorders in patients with genetic developmental and epileptic encephalopathies","volume":"101","author":"Veen 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