{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:17:22Z","timestamp":1783667842867,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n 22q11.2 deletion syndrome (22q11DS) is a multisystem genetic disorder associated with a significantly increased risk of early\u2010onset Parkinson's disease (EOPD). Management is challenging because psychiatric and cognitive comorbidities often limit advanced therapies such as deep brain stimulation (DBS).<\/jats:p>\n <\/jats:sec>\n \n Cases<\/jats:title>\n We report 2 patients with 22q11DS who developed EOPD at about age 30 with prominent psychiatric manifestations. In both cases, diagnosis of 22q11DS was delayed until genetic testing was performed for atypical parkinsonism associated with intellectual disability and dysmorphic features. Severe motor fluctuations and dyskinesia developed early. Because of psychiatric vulnerability, DBS and dopamine agonists were considered unsuitable. Continuous intrajejunal levodopa\u2013carbidopa infusion (LCIG [levodopa\u2013carbidopa intestinal gel]) was initiated, which led to sustained improvement in motor fluctuations and functional status, although individualized dose adjustments were required.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n LCIG may represent a valuable therapeutic option in selected patients with 22q11DS\u2010associated Parkinson's disease when psychiatric comorbidity limits other advanced therapies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70738","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:48:44Z","timestamp":1783666124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Intrajejunal Levodopa\u2013Carbidopa Infusion in Parkinson's Disease Associated with 22q11.2 Deletion Syndrome: A Case Series"],"prefix":"10.1002","author":[{"given":"Valle Victor","family":"Andr\u00e9s","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, NGERE Nancy France"},{"name":"Service de g\u00e9n\u00e9tique clinique CHRU de Nancy Nancy France"},{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, CHRU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jardel","family":"Amory","sequence":"additional","affiliation":[{"name":"Service de Neurologie CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hopes","family":"Lucie","sequence":"additional","affiliation":[{"name":"Service de Neurologie CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Guillemette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, NGERE Nancy France"},{"name":"Service de Neurologie CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert","family":"Laetitia","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, NGERE Nancy France"},{"name":"Service de g\u00e9n\u00e9tique clinique CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becker","family":"Aur\u00e9lie","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, CHRU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexheimer","family":"Myl\u00e8ne","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale, CHRU Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-0438","authenticated-orcid":false,"given":"Bonnet","family":"C\u00e9line","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, NGERE Nancy 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Neurologie CHR de Mercy Ars\u2010Lequenexy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00071-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001669"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005660"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33665"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173944"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12687"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20963"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00400-8"}],"container-title":["Movement Disorders Clinical 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