{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:49:13Z","timestamp":1791395353690,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subthalamic nucleus deep brain stimulation (STN DBS) improves Parkinson's disease (PD)\u2010related motor symptoms, but how STN DBS impacts various aspects of patient\u2010perceived health\u2010related quality of life (HRQoL) is less clear. The Patient\u2010Reported Outcome Measurement Instrument (PROMIS) and Quality of Life in Neurological Disorders (Neuro\u2010QoL), National Institutes of Health computer adaptive inventories, are T\u2010scored to a normative reference sample, and assesses 16 domains of a patient's HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This cross\u2010sectional study evaluated the convergent validity of a novel PROMIS\u2009+\u2009Neuro\u2010QoL aggregate measure, the construct validity of the aggregate and 16 PROMIS and Neuro\u2010QoL domains, and the responsiveness of these measures to change after STN DBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty eight people with PD completed the PROMIS, Neuro\u2010QoL, Parkinson's disease Questionnaire\u20108 (PDQ\u20108), and the Movement Disorder Society Unified Parkinson's Disease Rating Scale part III before surgery for STN DBS and at two follow\u2010up visits within 6 months after surgery. A Pearson correlation assessed the relationship between PROMIS\u2009+\u2009Neuro\u2010QoL aggregate and the PDQ\u20108, to determine convergent validity. One\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      tests compared preoperative scores to normative means. Finally, one\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      tests compared preoperative HRQoL and HRQoL after STN DBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PROMIS\u2009+\u2009Neuro\u2010QoL aggregate agreed strongly with the PDQ\u20108, providing convergent validation. Preoperatively, patients reported significantly worse\u2010than\u2010normative values of overall HRQoL, physical function, cognitive function, social health, fatigue, and mental health, providing construct validation. After DBS, the PROMIS\u2009+\u2009Neuro\u2010QoL aggregate, physical function, cognitive function, social health, and sleep improved, demonstrating responsiveness to change of the PROMIS and Neuro\u2010QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, these findings support the potential integration of the PROMIS and Neuro\u2010QoL in clinical and research settings in patients with PD to provide valuable insights into the patient's lived experience during DBS therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70739","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:34:51Z","timestamp":1784345691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of the\n                    <scp>PROMIS<\/scp>\n                    and Neuro\u2010\n                    <scp>QoL<\/scp>\n                    to Evaluate Health\u2010Related Quality of Life following Unilateral Subthalamic Deep Brain Stimulation for Parkinson's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-5233","authenticated-orcid":false,"given":"Sarah A.","family":"Brinkerhoff","sequence":"first","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Hurt","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Alabama at Birmingham, Heersink School of Medicine  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