{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:58:13Z","timestamp":1785383893405,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stiff person syndrome (SPS) is a rare disabling neurological condition with overlapping symptomatology with more common neurological conditions. Exaggerated exteroceptive reflex mechanisms are thought to play a role in its pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aim to describe the results of neurophysiological exteroceptive reflex testing in subjects with SPS, healthy controls, and other neurological conditions causing axial and lower limb muscle stiffness, pain and spasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a prospective cohort study, of 59 participants with a variety of neurological conditions, healthy controls and 11 with SPS. Retrospective data from participants with SPS who had prior exteroceptive reflex testing performed in an equivalent manner were also included in our analysis. Reflex responses were recorded by simultaneous surface electromyography (sEMG) of axial and lower limb muscles following repeated stimulation of the median and tibial nerves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Latencies following repeated activation of median and tibial nerves demonstrated a moderate to very strong correlation at most EMG recording sites within individuals. Using a mixed effects logistic model shorter mean latencies were observed in those with Parkinson's disease, healthy controls, low back pain and serotonergic\/noradrenergic antidepressant use compared with SPS following initial stimulation and when the shortest latency at each site within individual participants were analyzed. No study group differed significantly from SPS in the duration of responses following stimulation nor the presence or absence of after\u2010bursts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of exteroceptive testing as performed in this study did not differentiate SPS from other neurological conditions or healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70755","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:03:02Z","timestamp":1785380582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8383-1667","authenticated-orcid":false,"given":"Belinda","family":"Cruse","sequence":"first","affiliation":[{"name":"Department of Neurology Royal Melbourne Hospital  Parkville VIC Australia"},{"name":"Department of Medicine (RMH), Faculty of Medicine, Health and Dentistry The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Morales","family":"Briceno","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Melbourne Hospital  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Melbourne Hospital  Parkville VIC Australia"},{"name":"Department of Medicine (RMH), Faculty of Medicine, Health and Dentistry The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Qiu","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Kalincik","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Melbourne Hospital  Parkville VIC Australia"},{"name":"Department of Medicine (RMH), Faculty of Medicine, Health and Dentistry The University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mahant","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-2282","authenticated-orcid":false,"given":"Victor Shue Chung","family":"Fung","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology Westmead Hospital  Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0025-6196(26)01892-6","article-title":"Progressive fluctuating muscular rigidity and spasm (\u201cstiff\u2010man\u201d syndrome); 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