{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:49:11Z","timestamp":1785912551068,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["K23NR019099"],"award-info":[{"award-number":["K23NR019099"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA027264"],"award-info":[{"award-number":["R01AA027264"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Examine the longitudinal relationship between caregiver strain and Parkinson's patient depression, daytime sleepiness, and treatment with dopamine agonists and antidepressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is a neurodegenerative disorder, in which family caregivers play an integral role in patient care. Depression and daytime sleepiness in PD patients have been shown to influence caregiver strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a longitudinal analysis of PD patient sleep and depression measures, and a measure of caregiver strain. Strain scores were modeled as a function of: accumulated time between visits, PD patient depression and sleep scores, and their interactions with time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Caregiver strain increased over time, with patient depression and daytime sleepiness positively associated with greater caregiver strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient depressive symptoms consistently predicted caregiver strain, highlighting the central role of patient depression in caregiver well\u2010being. Routine caregiver evaluations during patient visits facilitate timely interventions that benefit patients and caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70759","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:13:31Z","timestamp":1785910411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Associations between Depression, Daytime Sleepiness, and Caregiver Strain in Parkinson's Disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9144-6901","authenticated-orcid":false,"given":"Sarah","family":"Holden","sequence":"first","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri  Columbia MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Christopher","sequence":"additional","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Mann","sequence":"additional","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H.","family":"Carter","sequence":"additional","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Quinn","sequence":"additional","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Xu","sequence":"additional","affiliation":[{"name":"Parkinson Center Oregon Health &amp; Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41531-020-0117-1","article-title":"Current and projected future economic burden of Parkinson's disease in the U.S","volume":"6","author":"Yang W","year":"2020","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.parkreldis.2005.06.011","article-title":"Caregiver\u2010burden in parkinson's disease is closely associated with psychiatric symptoms, falls, and disability","volume":"12","author":"Schrag A","year":"2006","journal-title":"Parkinsonism Relat 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