{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:16:55Z","timestamp":1788250615118,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower urinary tract symptoms (LUTS) are among the most prevalent nonmotor complaints across the parkinsonian spectrum, yet they remain underutilized as diagnostic and management signals in neurology practice. Although prior reviews have characterized disease\u2010specific patterns of urinary dysfunction, and recent guidelines address neurogenic LUTS broadly, no prior framework has explicitly focused on how the practicing neurologist can interpret LUTS as part of the diagnostic workup and integrate them into disease\u2010specific management across parkinsonian disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The aim of the review was to provide a neurology\u2010centered narrative review reframing LUTS as diagnostic clues in parkinsonism and to propose a practical clinical evaluation framework for neurologists. We conducted a narrative review of published literature on LUTS across parkinsonian disorders, identified through PubMed\/MEDLINE searches through March 2026, supplemented by manual review of reference lists and relevant guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Disease\u2010specific LUTS patterns can carry diagnostic relevance that can inform the neurologic differential diagnosis. Early urinary retention or elevated postvoid residual volume should raise suspicion for multiple system atrophy. Nocturia in Parkinson's disease is frequently multifactorial, requiring stepwise evaluation of dopaminergic timing, sleep disorders, nocturnal polyuria, and fluid shifts before bladder\u2010directed therapy is initiated. LUTS may interact with mobility and falls through urgency\u2010freezing convergence and nocturia\u2010orthostatic hypotension overlap. Antimuscarinic agents carry compounded risks of cognitive impairment, delirium, and falls in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A pragmatic framework using symptom classification, postvoid residual measurement, red flag identification, and targeted pharmacologic guidance can support safe and timely LUTS management within routine neurology practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70780","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:47:42Z","timestamp":1788248862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower Urinary Tract Symptoms as Diagnostic Clues in Parkinsonism: A Practical Framework for Neurologists"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-4505","authenticated-orcid":false,"given":"Saar","family":"Anis","sequence":"first","affiliation":[{"name":"Center for Neurological Restoration, Neurological Institute, Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Anis","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Institute Cleveland Clinic Foundation  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Lenka","sequence":"additional","affiliation":[{"name":"VCU Parkinson's Disease &amp; Movement Disorder Center, Virginia Commonwealth University  Richmond VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junaid H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Center for Neurological Restoration, Neurological Institute, Cleveland Clinic 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