{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:05:25Z","timestamp":1789200325848,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although regularly encountered, the groaning phenomenon in progressive supranuclear palsy (PSP) currently lacks systematic investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated the frequency and clinical phenomenology of groaning in PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed 180 patients with PSP, identifying groaning through examination and history. A specially designed questionnaire captured groaning characteristics (intensity, frequency, and triggers). Scores for the PSP Clinical Deficits Scale (PSP\u2010CDS), Barthel Index (BI), Short Cognitive and Neuropsychiatric Assessment (ShoCo) Scale, and modified Zarit Burden Interview (ZBI), and whole exome sequencing (WES) data, were extracted from our research database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six (20.0%) patients exhibited groaning, most of whom (77.8%) had Richardson's syndrome (PSP\u2010RS), which predicted groaning with an odds ratio (OR) of 4.1 (95% CI\u2009=\u20091.7\u201310.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Worse disease severity (PSP\u2010CDS) was also a predictive factor (OR\u2009=\u20091.2, 95% CI\u2009=\u20091.1\u20131.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Additionally, patients with groaning demonstrated worse longitudinal disease trajectory, alongside significantly greater functional disability (BI), cognitive\u2010behavioral impairment (ShoCo), and caregiver burden (ZBI). Groaning was typically moderate in intensity or loud, considered troublesome by caregivers and\/or patients, and triggers or reasons were commonly identified (in 76.0%). WES showed several patients carrying pathogenic\/likely pathogenic variants in genes potentially relevant to PSP (\n                      <jats:italic>MAPT<\/jats:italic>\n                      ,\n                      <jats:italic>GBA1<\/jats:italic>\n                      , and\n                      <jats:italic>SMPD1<\/jats:italic>\n                      ), but none carried the rare\n                      <jats:italic>NEFH<\/jats:italic>\n                      variant previously linked to familial moaning (p.Ile245Met).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides insights into a poorly understood feature of PSP and highlights a troublesome symptom that is associated with substantial patient and caregiver burden. Further work is needed to investigate the pathophysiological basis of groaning and to develop effective therapies for it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70785","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:52:18Z","timestamp":1788763938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Groaning in Progressive Supranuclear Palsy: Insights From a Large Asian Cohort"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2092-2605","authenticated-orcid":false,"given":"Ting Qing","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6762-0064","authenticated-orcid":false,"given":"Lu 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Manuscript under review."},{"issue":"1","key":"e_1_2_9_23_1","article-title":"Successful treatment of incessant purposeless groaning in progressive supranuclear palsy with pimozide","volume":"35","author":"Matta M","year":"2020","journal-title":"Mov Disord"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.02.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02158-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102152"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2011.06.002"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00363-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06783-0"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24016"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.18699\/vjgb-24-76"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0042-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.13009"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(26)00090-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00760-7"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00283-1"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00378-8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02421-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30141"},{"key":"e_1_2_9_41_1","unstructured":"Global Parkinson's Genetics Program (GP2).GBA1 Browser. 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