{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:56Z","timestamp":1789487576052,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression in Parkinson's disease (PD\u2010DD) is common, but little is known for outcomes after antidepressants are started.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We examine prescribing patterns and treatment trajectories for depression in Parkinson's disease (PD) in a Greek nationwide cohort (IDYKA) of 28,370 PD\u2010DD patients and 660,504 DD patients without PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Target trial emulation with propensity score weighting comparing SSRIs, non\u2010SSRI antidepressants, atypical antipsychotics (AAPs), and benzodiazepines on discontinuation and switching\/augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PD\u2010DD association (pooled OR 8.37, 95% CI 5.02\u201313.98) is age\u2010dependent in both sexes. Clinicians favored sedative agents, particularly mirtazapine (age\u2010 and gender\u2010adjusted OR [aOR] 1.26, 95% CI 1.22\u20131.30), duloxetine (1.41, 1.36\u20131.48), and quetiapine (1.33, 1.28\u20131.38). AAP were less commonly discontinued compared to SSRIs (HR 0.838 [0.771, 0.911]). Non\u2010SSRI ADs were associated with higher switch\/augmentation rates (1.155 [1.058, 1.240]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In PD depression, AAP outlast SSRIs in real\u2010world persistence and non\u2010SSRIs are more commonly switched or augmented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70809","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:43:54Z","timestamp":1789483434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depression in Parkinson's Disease: Real\u2010World Prescribing Patterns and Treatment Dynamics from a Nationwide Greek Cohort"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-9967","authenticated-orcid":false,"given":"Vasilios","family":"Karageorgiou","sequence":"first","affiliation":[{"name":"Second Department of Psychiatry University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-8051","authenticated-orcid":false,"given":"Petros","family":"Skapinakis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ioannina, School of Medicine  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-0218","authenticated-orcid":false,"given":"Ioannis","family":"Michopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Psychiatry University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7315-6918","authenticated-orcid":false,"given":"Panagiota","family":"Mitrou","sequence":"additional","affiliation":[{"name":"Hellenic Ministry of Health  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Thireos","sequence":"additional","affiliation":[{"name":"National Agency for Quality Assurance in Health S.A  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-1681","authenticated-orcid":false,"given":"Rossetos","family":"Gournellis","sequence":"additional","affiliation":[{"name":"Second Department of Psychiatry University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4834"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21383"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104749"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175070"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182516244"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(10)70986-X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(10)70248-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2025.101569"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21803"}],"container-title":["Movement 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Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:43:55Z","timestamp":1789483435000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":10,"alternative-id":["10.1002\/mdc3.70809"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70809","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2026-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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