{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:08:01Z","timestamp":1789020481928,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR\u2013M4C2\u2010I1.3 Project PE_00000019"],"award-info":[{"award-number":["PNRR\u2013M4C2\u2010I1.3 Project PE_00000019"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is associated with increased mortality and vascular\u2010metabolic comorbidity, but prognostic biomarkers are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the triglycerides\/high\u2010density lipoprotein cholesterol (TG\/HDL\u2010C) ratio, an insulin resistance (IR) marker, and its associations with MRI glymphatic markers and mortality in iNPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a dual\u2010center longitudinal study including 67 iNPH patients and 37 matched controls. Baseline lipid profiles were assessed, enlarged perivascular spaces (EPVS) were rated on 3\u2009T MRI in a subgroup, differences were tested by ANCOVA, and mortality associations by adjusted Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>iNPH patients showed higher triglycerides and TG\/HDL\u2010C and lower HDL\u2010C. High\u2010grade centrum semiovale (CSO)\u2010EPVS were associated with higher TG\/HDL\u2010C. TG\/HDL\u2010C showed the strongest mortality association. A model combining TG\/HDL\u2010C with CSO\u2010EPVS showed the best fit, suggesting synergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iNPH exhibits a lipid profile associated with IR linked to glymphatic alterations and mortality. Moreover, despite requiring large\u2010scale validation, combined\u2010marker models are promising.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70814","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:01:13Z","timestamp":1789020073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid\u2010Related Metabolic Dysregulation Affects Survival in Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2350-4121","authenticated-orcid":false,"given":"Jacopo","family":"Bissacco","sequence":"first","affiliation":[{"name":"Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"Neurology Unit\u2010IRCCS Neuromed  Pozzilli 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