{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:07:12Z","timestamp":1788937632784,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>JAK2<\/jats:italic>\n                      variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well\u2010recognized neurological occurrence in this context, whereas parkinsonism has received limited attention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To describe parkinsonian phenotypes in patients with\n                      <jats:italic>JAK2<\/jats:italic>\n                      \u2010mutated MPNs and explore possible pathophysiological links.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We identified five patients with a\n                      <jats:italic>JAK2<\/jats:italic>\n                      \u2010mutated MPNs and parkinsonism and reviewed their demographic and clinical features, neuroimaging, and levodopa response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Parkinsonian phenotypes were heterogeneous, including Parkinson's disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), atypical parkinsonism (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), motor neuron disease with parkinsonism (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), and chorea followed by parkinsonism (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). The latter patient developed parkinsonism approximately 22\u2009months after onset of generalized chorea. When available (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), DaTscan was abnormal. Levodopa responsiveness was variable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic>JAK2<\/jats:italic>\n                      \u2010mutated MPNs and parkinsonism may coexist coincidentally, recent evidence suggests plausible pathophysiological links, including vascular, inflammatory, immune\u2010mediated, and treatment\u2010related mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70815","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:44:31Z","timestamp":1788936271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>JAK2<\/i>\n                    Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3430-6764","authenticated-orcid":false,"given":"Elena Ardila","family":"Jurado","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8708-7506","authenticated-orcid":false,"given":"Koustubh","family":"Bavdhankar","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3370","authenticated-orcid":false,"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-6245","authenticated-orcid":false,"given":"Francesca","family":"Magrinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huw R.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-286X","authenticated-orcid":false,"given":"Kailash P.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London 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