{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:52:23Z","timestamp":1791208343894,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Essential tremor (ET) impacts daily activities and quality of life. A pivotal study of a transcutaneous peripheral nerve stimulation (TPNS) device, the Felix NeuroAI Wristband, led to Food and Drug Administration (FDA) clearance in 2025.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of the study was to report 1\u2010year follow\u2010up results.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients who completed the 90\u2010day randomized phase could continue until 1\u2009year after the baseline visit; those in the sham group were crossed over to active TPNS treatment (delayed\u2010start TPNS). Outcome measures were assessed at 180\u2009days and 1\u2009year: modified Activities of Daily Living (mADL) subscale of TETRAS, Clinical and Patient Global Impression of Improvement (CGI\u2010I and PGI\u2010I), Quality of Life in Essential Tremor Questionnaire, and adverse device effects (ADEs).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 93 patients who entered the extension phase (58 TPNS and 35 delayed start), 57 (38 and 19, respectively) completed 1\u2009year of follow\u2010up. In the TPNS group, mADL improvement increased from 6.9 points at day 90 to 9.7 points at 1\u2009year. Ninety days of active treatment improved mADL scores by 5.5 points in the delayed\u2010start TPNS group (day 180). From baseline, TETRAS ADL scores in the TPNS group improved by 6.1\u2009\u00b1\u20096.0 points at 90\u2009days and 9.3\u2009\u00b1\u20096.0 points at 1\u2009year. CGI\u2010I, PGI\u2010I, and quality of life improved in both groups from 90\u2009days to 1\u2009year. Twenty\u2010three new ADEs occurred (mild skin irritation, n\u2009=\u200922; muscle spasms, n\u2009=\u20091).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n TPNS use was associated with sustained functional improvement for up to 1\u2009year with acceptable safety. Patients who initiated active therapy earlier demonstrated greater cumulative benefit.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70833","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:00:16Z","timestamp":1791205216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of the Felix\n NeuroAI<\/scp>\n Wristband for Essential Tremor: Results of a 1\u2010Year Open\u2010Label Extension Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-5706","authenticated-orcid":false,"given":"Stuart H.","family":"Isaacson","sequence":"first","affiliation":[{"name":"Parkinson's Disease and Movement Disorder Center of Boca Raton Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-584X","authenticated-orcid":false,"given":"Yongsheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Ondo","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Lv","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-4606","authenticated-orcid":false,"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital Heping China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-136X","authenticated-orcid":false,"given":"Alberto J.","family":"Espay","sequence":"additional","affiliation":[{"name":"University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kreitzman","sequence":"additional","affiliation":[{"name":"Parkinson's Research Centers of America \u2010 Long Island Commack New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-931X","authenticated-orcid":false,"given":"Sheng\u2010Han","family":"Kuo","sequence":"additional","affiliation":[{"name":"Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Brillman","sequence":"additional","affiliation":[{"name":"Parkinson's Research Center of America\u2014Palo Alto Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Shill","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Lyons","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Fasikl Inc Bloomington Minnesota USA"},{"name":"University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fasikl Inc Bloomington Minnesota USA"},{"name":"University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0804-8741","authenticated-orcid":false,"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fasikl Inc Bloomington Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-6466","authenticated-orcid":false,"given":"Rajesh","family":"Pahwa","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02318-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02926.x"},{"key":"e_1_2_9_4_1","unstructured":"US Food & Drug Administration.Felix NeuroAI System 510(k) Premarket Notification;2025. Updated Jan. 19 2026. Accessed January 2 2026 https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfPMN\/pmn.cfm?ID=K250096."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.3905"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25162"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.106086"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.29245\/2572.942X\/2016\/4.1038"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060937"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809335"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:00:18Z","timestamp":1791205218000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":10,"alternative-id":["10.1002\/mdc3.70833"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70833","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"mdc3.70833"}}