{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:50:54Z","timestamp":1791183054612,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Foslevodopa\/foscarbidopa (LDp\/CDp) infusion may reduce PD\u2010related pain; however, its effects on different pain manifestations remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim was to evaluate longitudinal changes in overall and domain\u2010specific PD\u2010related pain after LDp\/CDp infusion.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twenty\u2010six patients with advanced PD initiating LDp\/CDp infusion underwent evaluation at baseline (T0) and 6\u2009months (T1). Pain was assessed using the King's Parkinson's Disease Pain Scale (KPPS). Secondary outcomes included motor complications, quality of life (QoL), dopaminergic treatment burden, and pain\u2013motor correlations.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At T1, KPPS total score decreased (9.6\u2009\u00b1\u20096.5 vs. 2.7\u2009\u00b1\u20094.7,\n P<\/jats:italic>\n \u2009<\u20090.001), with improvements in chronic (\n P<\/jats:italic>\n \u2009=\u20090.01), fluctuation\u2010related (\n P<\/jats:italic>\n \u2009<\u20090.001), and nocturnal (\n P<\/jats:italic>\n \u2009<\u20090.001) pain. Motor complications reduced (\n P<\/jats:italic>\n \u2009<\u20090.001), and fluctuation\u2010related pain reduction correlated with motor complication changes (\u03c1\u2009=\u20090.46,\n P<\/jats:italic>\n \u2009=\u20090.04). QoL improved (\n P<\/jats:italic>\n \u2009=\u20090.006), whereas dopaminergic treatment burden was unchanged.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n LDp\/CDp infusion improved PD\u2010related pain, particularly chronic, fluctuation\u2010related, and nocturnal pain, with a parallel improvement in QoL, suggesting benefits beyond motor complication management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70849","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:52:13Z","timestamp":1791179533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Continuous Subcutaneous Foslevodopa\/Foscarbidopa Infusion on Parkinson's Disease\u2013Related Pain: A 6\u2010Month Real\u2010World Longitudinal Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5299-2123","authenticated-orcid":false,"given":"Kristi","family":"Meksi","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Neuromed Istituto Neurologico Mediterraneo Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3269-8684","authenticated-orcid":false,"given":"Clara","family":"Simonetta","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Neuromed Istituto Neurologico Mediterraneo Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4247-2924","authenticated-orcid":false,"given":"Giovanni","family":"Minutilli","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2879-2209","authenticated-orcid":false,"given":"Matteo","family":"Conti","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9645-9168","authenticated-orcid":false,"given":"Francesca","family":"Avvento","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-6278","authenticated-orcid":false,"given":"Tommaso","family":"Schirinzi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Neuromed Istituto Neurologico Mediterraneo Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8545","authenticated-orcid":false,"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Neuromed Istituto Neurologico Mediterraneo Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1806-8922","authenticated-orcid":false,"given":"Alessandro","family":"Stefani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"UOSD Parkinson Centre Tor Vergata University Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pierantozzi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"IRCCS Neuromed Istituto Neurologico Mediterraneo Pozzilli Italy"},{"name":"UOSD Parkinson Centre Tor Vergata University Hospital Rome 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