{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:17:53Z","timestamp":1791044273521,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,11]],"date-time":"2002-03-11T00:00:00Z","timestamp":1015804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2002,3,11]],"date-time":"2002-03-11T00:00:00Z","timestamp":1015804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We studied the effect of high\u2010frequency electrical stimulation of the ventral\u2010intermediate nucleus of the thalamus (Vim) in four patients implanted with chronic stimulators to determine whether this procedure adversely affects reaction time to a proprioceptive stimulus. Two patients had undergone this surgery for treatment of tremor resulting from Parkinson's disease insufficiently responsive to levodopa therapy and two patients for treatment of essential tremor. Reaction times to auditory, visual, cutaneous, and proprioceptive stimuli were tested in a simple motor task requiring flexion of the elbow joint to a visual target in response to each stimulus. Reaction times were tested postoperatively with and without the stimulator turned on. We found that reaction time for all stimulus modalities was not increased when the stimulator was turned on; in fact, reaction times were, on average, slightly shorter during stimulation, but this difference was not statistically significant. We conclude that transmission of somatosensory inputs, necessary for initiating voluntary movement, from the periphery to the cortex is not significantly impaired by stimulation of the ventral\u2010intermediate nucleus of the thalamus in patients with pathological tremor. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10120","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T07:25:39Z","timestamp":1033889139000},"page":"488-492","source":"Crossref","is-referenced-by-count":4,"title":["Reaction time is not impaired by stimulation of the ventral\u2010intermediate nucleus of the thalamus (Vim) in patients with tremor"],"prefix":"10.1002","volume":"17","author":[{"given":"Didier","family":"Flament","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin D.","family":"Pfann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charity G.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Penn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Corcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"299","volume-title":"Neurosurgical operative atlas","author":"Bakay RAE","year":"1992"},{"key":"e_1_2_6_3_2","first-page":"344","article-title":"Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease","volume":"50","author":"Benabid AL","year":"1987","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050050014"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-8482-0_17"},{"key":"e_1_2_6_6_2","first-page":"89","article-title":"D\u00e9rivations d'activit\u00e9es spontan\u00e9es et \u00e9voqu\u00e9es dans les structures c\u00e9r\u00e9brales profondes de l'homme","volume":"106","author":"Albe\u2010Fessard D","year":"1962","journal-title":"Rev Neurol"},{"key":"e_1_2_6_7_2","first-page":"237","volume-title":"The thalamus","author":"Albe\u2010Fessard D","year":"1966"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.6.1795"},{"key":"e_1_2_6_9_2","first-page":"316","article-title":"Cell sparse zones in the ventrolateral thalamic mass in humans, monkeys and cats: their special reference to kinesthetic neurons","volume":"48","author":"Hirai T","year":"1985","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.50.3.0290"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.61.3.488"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.1.267"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080419"},{"key":"e_1_2_6_14_2","first-page":"32P","article-title":"Stimulation and recording from the nucleus ventralis intermedius (Vim) in a patient with Parkinson's disease","volume":"483","author":"Rothwell J","year":"1995","journal-title":"J Physiol (Lond)"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1973.39.2.0214"},{"key":"e_1_2_6_16_2","first-page":"376","article-title":"Microstimulation\u2010induced effects on neurons in globus pallidus and motor thalamus","volume":"25","author":"Dostrovsky JO","year":"1999","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_17_2","first-page":"285","article-title":"Physiologically defined VIM nucleus. Its special reference to control of tremor","volume":"39","author":"Ohye C","year":"1976","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00480030080008"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.7.782"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100205"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.10120","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.10120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:12:13Z","timestamp":1775797933000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.10120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,11]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/mds.10120"],"URL":"https:\/\/doi.org\/10.1002\/mds.10120","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,11]]}}}