{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:58:56Z","timestamp":1778007536821,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,3,29]],"date-time":"2002-03-29T00:00:00Z","timestamp":1017360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paraoxonase1 (PON1) is an arylesterase mainly expressed in the liver that hydrolyzes organophosphates such as pesticides, reported risk factors for Parkinson's disease (PD), and other neurotoxins. A Leu\u2010Met 54 polymorphism in the gene for PON1\u2010affecting enzyme activity was recently shown, employing a new restriction enzyme technique, to be associated with Parkinson's disease. We examined the same polymorphism by automated capillary sequencing in a sample of Caucasian subjects from the Stockholm area in Sweden (127 healthy individuals and 114 patients with PD) and found similar distributions and a similar difference in our sample. The genotype distribution in our PD material was LL 36.0%, LM 45.6%, and MM 18.4%; in our control material, it was LL 45.7%, LM 44.1%, and MM 10.2%. Based on the previously established increase in allele frequencies of the lower\u2010activity Met\u2010variant of PON1, we could confirm a significant association using a one\u2010sided \u03c7<jats:sup>2<\/jats:sup> test. Results remained significant with a two\u2010sided \u03c7<jats:sup>2<\/jats:sup> test, allowing for both increases and decreases in frequencies. Our data confirm an association between the PON1 Leu\u2010Met 54 polymorphism and PD by demonstrating a similar association. The distribution between familial and nonfamilial PD patients was equal. No other synonymous or nonsynonymous polymorphisms were found in the sequenced coding region of PON1. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10172","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T07:44:15Z","timestamp":1033890255000},"page":"764-766","source":"Crossref","is-referenced-by-count":41,"title":["Further evidence for an association of the Paraoxonase 1 (PON1) Met\u201054 allele with Parkinson's disease"],"prefix":"10.1002","volume":"17","author":[{"given":"Andrea","family":"Carmine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Buervenich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Sydow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Anvret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"An essay on the shaking palsy","author":"Parkinson J","year":"1817"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1197"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/33416"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(99)80077-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9169"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-334"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1649"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00095-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90215-O"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61755-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118359"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80962-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1564"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<813::AID-MDS1008>3.0.CO;2-Y"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00193-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0193-73"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.2935"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119134"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00439-7"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200011)15:6<1265::AID-MDS1034>3.0.CO;2-0"},{"key":"e_1_2_6_23_2","first-page":"165","article-title":"Parkinson's Disease Society Brain Bank, London: overview and research","volume":"39","author":"Daniel SE","year":"1993","journal-title":"J Neural Transm"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.10172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:26:30Z","timestamp":1760955990000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.10172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1002\/mds.10172"],"URL":"https:\/\/doi.org\/10.1002\/mds.10172","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}