{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:42:13Z","timestamp":1791024133204,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,17]],"date-time":"2002-04-17T00:00:00Z","timestamp":1019001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present the efficacy and side effects of bilateral deep brain stimulation (DBS) of the subthalamic nuclei (STN) performed with a more simplified surgical procedure than described by the Grenoble group. A consecutive series of 26 patients with advanced and levodopa\u2010responsive Parkinson's disease and motor complications was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) part I\u2013VI, timed tests, and a patient diary for 2 days concerning <jats:italic>on\u2013off<\/jats:italic> phenomenon and dyskinesias. At 3 months, evaluation of stimulation by the UPDRS motor score was performed in a double\u2010blind manner and a significant improvement of 57% was found. The results 12 months after surgery <jats:italic>off<\/jats:italic> medication showed significant improvement in both UPDRS motor score and activities of daily living of 64% and, <jats:italic>on<\/jats:italic> medication, a significant reduction of 86% in duration of dyskinesias and 83% in duration of <jats:italic>off<\/jats:italic>\u2010periods. Reduction in medication was less than for other groups, probably because we used smaller doses of levodopa before the operation. No serious side effects were encountered. When the patients are carefully selected and followed up, bilateral DBS of STN is a significant progress in treatment of advanced idiopathic Parkinson's disease with levodopa\u2010induced motor complications. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10188","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T07:44:15Z","timestamp":1033890255000},"page":"693-700","source":"Crossref","is-referenced-by-count":161,"title":["Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations"],"prefix":"10.1002","volume":"17","author":[{"given":"Karen","family":"\u00d8stergaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Sunde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810083391506"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1090"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422004"},{"issue":"5","key":"e_1_2_6_5_2","first-page":"S17","article-title":"Early treatment of Parkinson's disease with cabergoline delays the onset of motor complications: results of a double\u2010blind levodopa controlled 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