{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:23:56Z","timestamp":1760955836532,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,4,10]],"date-time":"2002-04-10T00:00:00Z","timestamp":1018396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on a patient with cranio\u2013cervical dystonia injected with the new, lower protein formulation of botulinum toxin A who developed secondary resistance to this toxin. Subsequent injections with botulinum toxin B provided substantial reduction of blepharospasm. This is the first reported case of secondary resistance to the new preparation of botulinum toxin A. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10209","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T01:25:39Z","timestamp":1034126739000},"page":"1098-1100","source":"Crossref","is-referenced-by-count":10,"title":["Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024)"],"prefix":"10.1002","volume":"17","author":[{"given":"Brad A.","family":"Racette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikula","family":"Stambuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Perlmutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.1999.tb00032.x"},{"key":"e_1_2_5_3_2","first-page":"275","article-title":"Evaluation of Botox manufactured from a new bulk toxin in the open label treatment of cervical dystonia","volume":"13","author":"O'Brien C","year":"1998","journal-title":"Mov Disord"},{"key":"e_1_2_5_4_2","first-page":"6","article-title":"Efficacy and safety of a new bulk toxin of botulinum toxin in cervical dystonia: a blinded evaluation","volume":"22","author":"Racette BA","year":"1999","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92070-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1624"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1439"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1431"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090216"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1743"},{"key":"e_1_2_5_11_2","first-page":"A521","article-title":"Botox (botulinum toxin type A) purified neurotoxin complex prepared from the new bulk toxin retains the same preclinical efficacy as the original but with reduced immunogenicity","volume":"52","author":"Aoki R","year":"1999","journal-title":"Neurology"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.10209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:27:02Z","timestamp":1760952422000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.10209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/mds.10209"],"URL":"https:\/\/doi.org\/10.1002\/mds.10209","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2002,4,10]]}}}