{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:01:58Z","timestamp":1784401318241,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,4,10]],"date-time":"2002-04-10T00:00:00Z","timestamp":1018396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Magnetic resonance imaging (MRI) and <jats:sup>1<\/jats:sup>H magnetic resonance spectroscopy (MRS) of the substantia nigra, basal ganglia, and cerebral cortex were performed on 10 patients with Parkinson's disease (PD) and 13 age\u2010matched, healthy control subjects. Compared to controls, PD patients had approximately 24% lower creatine in the region of the substantia nigra and smaller volumes of the putamen (11%), globus pallidus (16%), and prefrontal cortex (6%; all <jats:italic>P<\/jats:italic> &lt; 0.05). No other significant between\u2010group differences were found in nine regions examined. Thus, quantitative MRI may show regional neurodegenerative changes outside the substantia nigra in PD but PD\u2010linked extranigral metabolic abnormalities, if they exist, may be difficult to detect with current <jats:sup>1<\/jats:sup>H MRS methods. In additional, exploratory tests, volumes of the caudate (r = \u22120.56), putamen (r = \u22120.66), and globus pallidus (r = \u22120.60; all <jats:italic>P<\/jats:italic> &lt; 0.05) were negatively correlated with the volume of the substantia nigra pars compacta in controls. In PD these correlations did not hold. Instead, pallidal volume in PD was positively correlated with compacta volume (r = 0.64; <jats:italic>P<\/jats:italic> &lt; 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10214","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T01:25:39Z","timestamp":1034126739000},"page":"917-927","source":"Crossref","is-referenced-by-count":94,"title":["Quantitative <sup>1<\/sup>H magnetic resonance spectroscopy and MRI of Parkinson's disease"],"prefix":"10.1002","volume":"17","author":[{"given":"Joseph","family":"O'Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William J.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Feiwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Aminoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330502"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.1033"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050171"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07824.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200618"},{"key":"e_1_2_6_7_2","first-page":"697","article-title":"Structural changes of the substantia nigra in Parkinson's disease as revealed by MR imaging","volume":"21","author":"Hutchinson M","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.6.1138"},{"key":"e_1_2_6_9_2","first-page":"157","article-title":"L'IRM dans les syndromes extrapyramidaux d'origine d\u00e9g\u00e9n\u00e9rative. La maladie de Parkinson, la paralysie supranucl\u00e9aire progressive et l'atrophie syst\u00e9matis\u00e9e multiple","volume":"23","author":"Elkeslassy A","year":"1996","journal-title":"J Neuroradiol"},{"key":"e_1_2_6_10_2","first-page":"13","article-title":"Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging","volume":"40","author":"Lisanby SH","year":"1993","journal-title":"J Neural Transm"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<65::AID-ART12>3.0.CO;2-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-00981.1993"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02033352"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(97)00032-X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111347"},{"key":"e_1_2_6_16_2","first-page":"234","volume-title":"Metabolite levels at three brain locations in parkinsonism as viewed by proton MRS","author":"Heerschap A","year":"1993"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199808000-00005"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/1353-8020(96)00007-7"},{"issue":"1","key":"e_1_2_6_19_2","first-page":"178","article-title":"In vivo localized proton MR spectroscopy in the striatum in Parkinson's disease","volume":"11","author":"Simoes F","year":"1996","journal-title":"Mov Disord"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.438"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.1.20"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(97)00079-9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370211"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.3.239"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.9.1541"},{"key":"e_1_2_6_26_2","first-page":"161","article-title":"Proton MR spectroscopy of the brain in 14 patients with Parkinson disease","volume":"16","author":"Bowen BC","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_27_2","first-page":"115","article-title":"Tissue segmentation of the brain in Alzheimer's disease","volume":"18","author":"Tanabe J","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.207.1.9530304"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(87)90154-5"},{"key":"e_1_2_6_30_2","first-page":"621","article-title":"Subcortical ischemic vascular dementia: role of quantitative MRI and 1HMRSI in assessment and diagnosis","volume":"21","author":"Capizzano AA","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/30\/4\/008"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400607"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350509"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1119"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0929-693X(96)81250-4"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-00981.1993"},{"key":"e_1_2_6_37_2","unstructured":"SchuffN CapizzanoAA DuAT AmendD O'NeillJ NormanD JagustW MillerB WolkowitzO YaffeK WeinerMW.Selective reduction of N\u2010acetylaspartate in hippocampus and parietal gray matter in Alzheimer's disease(submitted)."},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530320063013"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(95)02729-H"},{"key":"e_1_2_6_40_2","first-page":"304","article-title":"Regional brain atrophy in idiopathic Parkinson's disease and diffuse Lewy body disease","volume":"7","author":"Double KL","year":"1996","journal-title":"Dementia"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.3.268"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.340"},{"issue":"46","key":"e_1_2_6_43_2","first-page":"15","article-title":"Nigral and extranigral pathology in Parkinson's disease","author":"Braak H","year":"1995","journal-title":"J Neural Transm"},{"key":"e_1_2_6_44_2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1176\/ajp.155.6.774","article-title":"Decreased caudate volume in neuroleptic\u2010naive schizophrenics","volume":"155","author":"Keshavan MS","year":"1998","journal-title":"Am J Psychiatry"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.8.1200"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00100-7"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07828.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.159.2.3961182"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.10214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.10214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:26:12Z","timestamp":1760952372000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.10214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,10]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/mds.10214"],"URL":"https:\/\/doi.org\/10.1002\/mds.10214","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,10]]}}}