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However, some aspects of this response remain unclear. In this work, different electrophysiological and neurochemical parameters were studied in GABAergic cells of the SN after unilateral nigrostriatal dopaminergic lesion using 6\u2010hydroxydopamine injection in rats. Our data showed that 1) the SN under normal conditions contains different subsets of GABAergic cells according to their firing pattern and glutamic acid decarboxylase mRNA levels, and 2) the response of these GABAergic cell subgroups was different after the ipsi\u2010 and contralateral dopaminergic cell degeneration. These findings indicate a complex regulation of nigral GABAergic activity after nigrostriatal dopaminergic degeneration that probably involves local mechanisms, the nigro\u2010striato\u2010nigral loop, as well as interhemispheric mechanisms whose anatomical basis remains unstudied. \u00a9 2002 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10345","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T17:59:21Z","timestamp":1048010361000},"page":"254-266","source":"Crossref","is-referenced-by-count":15,"title":["Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65\/GAD67 expression in the substantia nigra: Different action on GABA cell subpopulations"],"prefix":"10.1002","volume":"18","author":[{"given":"Manuel 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