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Linkage to the SGCE locus has been detected in the majority of families tested, and mutations in the coding region have been found recently in families with autosomal dominant myoclonus\u2013dystonia. To evaluate the relevance of SGCE in myoclonus\u2013dystonia, we sequenced the entire coding region of the \u03f5\u2010sarcoglycan gene in 16 patients with either sporadic or familial myoclonus\u2013dystonia. No mutations were found. This study suggests that \u03f5\u2010sarcoglycan does not play an important role in sporadic myoclonus\u2013dystonia and supports genetic heterogeneity in familial cases. \u00a9 2003 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10476","type":"journal-article","created":{"date-parts":[[2003,9,16]],"date-time":"2003-09-16T09:36:12Z","timestamp":1063704972000},"page":"1047-1051","source":"Crossref","is-referenced-by-count":44,"title":["Analysis of the \u03f5\u2010sarcoglycan gene in familial and sporadic myoclonus\u2010dystonia: Evidence for genetic 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