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To establish whether a nigral glutathione deficiency is unique to PD, as is generally assumed, or is present in other Parkinsonian conditions associated with nigral damage, we compared levels of reduced glutathione (GSH) in postmortem brain of patients with PD to those with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). As compared with the controls, nigral GSH levels were decreased in the PD and PSP patient groups (<jats:italic>P<\/jats:italic> &lt; 0.05 for PD [\u221230%], PSP [\u221221%]), whereas a similar decrease in the MSA patient group did not reach statistical significance (<jats:italic>P<\/jats:italic> = 0.078, MSA [\u221220%]). GSH levels were normal in all examined normal and degenerating extra\u2010nigral brain areas in PSP and MSA. A trend for decreased levels of uric acid (antioxidant and product of purine catabolism) also was observed in nigra of all patient groups (\u221219 to \u221230%). These data suggest that glutathione depletion, possibly consequent to overutilisation in oxidative stress reactions, could play a causal role in nigral degeneration in all nigrostriatal dopamine deficiency disorders, and that antioxidant therapeutic approaches should not be restricted to PD. \u00a9 2003 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10486","type":"journal-article","created":{"date-parts":[[2003,9,16]],"date-time":"2003-09-16T09:36:12Z","timestamp":1063704972000},"page":"969-976","source":"Crossref","is-referenced-by-count":65,"title":["Nigral glutathione deficiency is not specific for idiopathic Parkinson's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Paul 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