{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:57:40Z","timestamp":1790553460083,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T00:00:00Z","timestamp":1069200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The presynaptic protein \u03b1\u2010synuclein is considered to play an important role in the pathophysiology of Parkinson's disease (PD). Point mutations in the \u03b1\u2010synuclein gene have been demonstrated in familial PD and \u03b1\u2010synuclein is a major component of Lewy bodies, the pathological hallmark of the sporadic disease. It is not clear whether abnormal accumulation of \u03b1\u2010synuclein is the result of abnormal levels of expression of the gene in neurodegenerative conditions. Expression of \u03b1\u2010synuclein mRNA was therefore studied in control and PD brain using semiquantitative in situ hybridization. \u03b1\u2010synuclein was expressed widely and hybridization signal was seen in most cortical regions, hippocampus, cerebellum, and brain stem. There was little mRNA in the striatum and no hybridization signal was detected in glia. High levels of \u03b1\u2010synuclein mRNA expression in neurons did not seem to be a marker for Lewy body formation. Abundant signal was seen both in regions in which Lewy body deposition occurs commonly in idiopathic PD (PD), such as substantia nigra and frontal and temporal cortex, as well as in less susceptible regions, e.g. visual cortex. Quantitative comparison of mRNA expression in regions of predilection for Lewy body formation showed that mRNA expression was reduced significantly in melanized substantia nigra neurons and frontal cortex neurons in Parkinson's disease. In substantia nigra neurons there seemed to be a negative correlation between cellular mRNA expression and disease duration. These findings are in broad agreement with other studies of the expression of \u03b1\u2010synuclein mRNA in human brain and suggest that Lewy body formation is unlikely to be the result of overexpression of \u03b1\u2010synuclein. \u00a9 2003 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.10683","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T04:00:27Z","timestamp":1076990427000},"page":"162-170","source":"Crossref","is-referenced-by-count":92,"title":["Alteration in \u03b1\u2010synuclein mRNA expression in Parkinson's disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Ann E.","family":"Kingsbury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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