{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:11:50Z","timestamp":1790809910062,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,5,9]],"date-time":"2001-05-09T00:00:00Z","timestamp":989366400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to investigate the long\u2010term safety and efficacy of unilateral deep brain stimulation (DBS) of the VIM nucleus of the thalamus in essential tremor. Forty\u2010nine patients were evaluated for DBS between December 1993 and March 1998. Tremor was assessed by a clinical rating scale at 3 and 12 months and then yearly. Three patients were not implanted, seven were explanted prior to 24 months, 11 were lost to long\u2010term follow\u2010up, and three died from unrelated causes. Twenty\u2010five patients were evaluated with follow\u2010up greater than or equal to 2 years. The last postsurgical follow\u2010up occurred on average 40.2 \u00b1 14.7 months after surgery. Tremor scores were significantly improved with stimulation on at the long\u2010term follow\u2010up as compared to baseline. There was no change in tremor scores from baseline to long\u2010term follow\u2010up with stimulation off. There was no significant change in any stimulus parameters from 3 months to the long\u2010term follow\u2010up. Three patients had asymptomatic intracerebral hemorrhages and one patient had postoperative seizures. Stimulus\u2010related adverse reactions were mild and easily controlled with changes in stimulus parameters. Device\u2010related complications were common and required repeated surgical procedures. Unilateral DBS of the thalamus has long\u2010term efficacy in some patients for treatment of essential tremor. However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures. \u00a9 2001 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.1089","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T14:54:07Z","timestamp":1030287247000},"page":"464-468","source":"Crossref","is-referenced-by-count":250,"title":["Long\u2010term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor"],"prefix":"10.1002","volume":"16","author":[{"given":"William C.","family":"Koller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Troster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Pahwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,5,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"365","volume-title":"Movement disorders","author":"Koller W","year":"1997"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.12.1982"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350613"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1962.04210020051006"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103460"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.3.0296"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000100201"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.6.0924"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199510000-00011"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91175-T"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.77.1.0062"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01411439"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.2.0203"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1150"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6513-3_9"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420304"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1063"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.3.289"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.1.0068"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002173420703"},{"key":"e_1_2_5_22_2","first-page":"195","volume-title":"Handbook of tremor disorders","author":"Deuschl G","year":"1995"},{"key":"e_1_2_5_23_2","first-page":"271","volume-title":"Parkinson's disease and movement disorders","author":"Fahn S","year":"1993"},{"key":"e_1_2_5_24_2","unstructured":"PahwaR LyonsKE WilkinsonSB et al.Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor. 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