{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:41:19Z","timestamp":1760960479704,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,7,11]],"date-time":"2001-07-11T00:00:00Z","timestamp":994809600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Doxorubicin chemomyectomy is a potent method for the permanent removal of a muscle or group of muscles after direct local injection, and has been used successfully to treat blepharospasm and hemifacial spasm patients. The efficacy of doxorubicin chemomyectomy on reducing muscle strength after direct injection of doxorubicin into rabbit sternocleidomastoid muscle was tested. One\u2010 and 6\u2010month postinjection force assessment was performed in vitro to measure alterations in peak twitch and tetanic force generation, as well as fatigue responses for the treated muscles compared to control. There were significant reductions of both twitch and tetanic peak amplitudes in the doxorubicin\u2010treated muscles. One month after treatment, the decreases in force were greater after 2 mg doxorubicin injections than after 1 mg doxorubicin. While there was a significant reduction in force generation after doxorubicin treatment, fatigue resistances for the doxorubicin\u2010treated muscles were increased compared to the controls. There were significant reductions in muscle mass after doxorubicin treatment, and by 6 months, the myosin heavy chain isoform distribution was similar to normal sternocleidomastoid, except for an increase in slow myosin\u2010positive fibers. Doxorubicin chemomyectomy resulted in a significant reduction in functional force generation in the treated sternocleidomastoid muscles. These findings suggest a potential clinical use of doxorubicin chemomyectomy to treat cervical dystonia patients. \u00a9 2001 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.1125","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T14:54:07Z","timestamp":1030287247000},"page":"683-692","source":"Crossref","is-referenced-by-count":8,"title":["Physiological assessment of muscle strength in vitro after direct injection of doxorubicin into rabbit sternocleidomastoid muscle"],"prefix":"10.1002","volume":"16","author":[{"given":"Jon H.","family":"Falkenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Iaizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda K.","family":"McLoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,26]]},"reference":[{"volume-title":"Doxorubicin: anticancer antibiotics","year":"1981","author":"Arcamone F","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120504"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00122115"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90040-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1995.tb02316.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060206"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1972.52.1.129"},{"key":"e_1_2_6_9_2","first-page":"473","article-title":"Spasmodic torticollis: clinical and biologic features and their implications for focal dystonia","volume":"50","author":"Duane DD","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013275"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020073"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020270"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290407"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61722-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.1.481"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90023-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.2.538"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00247939"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64520-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.2.258"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00011-2"},{"key":"e_1_2_6_22_2","first-page":"1667","article-title":"Quantification of muscle loss in the doxorubicin\u2010treated orbicularis oculi of the monkey. 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