{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:55:56Z","timestamp":1791104156047,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,9,20]],"date-time":"2001-09-20T00:00:00Z","timestamp":1000944000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used positron emission tomography (PET) with <jats:sup>15<\/jats:sup>O\u2010labelled water to record patterns of cerebral activation in six patients with Parkinson's disease (PD), studied when clinically \u201coff\u201d and after turning \u201con\u201d as a result of dopaminergic stimulation. They were asked to imagine a finger opposition movement performed with their right hand, externally paced at a rate of 1 Hz. Trials alternating between motor imagery and rest were measured. A pilot study of three age\u2010matched controls was also performed. We chose the task as a robust method of activating the supplementary motor area (SMA), defects of which have been reported in PD. The PD patients showed normal degrees of activation of the SMA (proper) when both \u201coff\u201d and \u201con.\u201d Significant activation with imagining movement also occurred in the ipsilateral inferior parietal cortex (both \u201coff\u201d and when \u201con\u201d) and ipsilateral premotor cortex (when \u201coff\u201d only). The patients showed significantly greater activation of the rostral anterior cingulate and significantly less activation of the left lingual gyrus and precuneus when performing the task \u201con\u201d compared with their performance when \u201coff.\u201d PD patients when imagining movement and \u201coff\u201d showed less activation of several sites including the right dorsolateral prefrontal cortex (DLPFC) when compared to the controls performing the same task. No significant differences from controls were present when the patients imagined when \u201con.\u201d Our results are consistent with other studies showing deficits of pre\u2010SMA function in PD with preserved function of the SMA proper. In addition to the areas of reduced activation (anterior cingulate, DLPFC), there were also sites of activation (ipsilateral premotor and inferior parietal cortex) previously reported as locations of compensatory overactivity for PD patients performing similar tasks. Both failure of activation and compensatory changes are likely to contribute to the motor deficit in PD. \u00a9 2001 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.1181","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:15:54Z","timestamp":1030295754000},"page":"849-857","source":"Crossref","is-referenced-by-count":54,"title":["Motor imagery in Parkinson's disease: A PET 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