{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:08:17Z","timestamp":1790665697423,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,9,20]],"date-time":"2001-09-20T00:00:00Z","timestamp":1000944000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The decision to treat patients with essential tremor (ET) is based primarily on the functional impact of the tremor. Correlates of functional disability, apart from the severity of the tremor itself, have not been studied. The objective of this work was to study correlates of functional disability in ET, and to present data on the extent of functional disability in community\u2010dwelling ET cases.<\/jats:p>\n                  <jats:p>ET cases and age\u2010matched control subjects were ascertained from a tertiary referral center at Columbia\u2010Presbyterian Medical Center and a community in northern Manhattan, N.Y. Subjects underwent a 2.5\u2010hour evaluation, including a tremor disability questionnaire, a videotaped tremor examination rated by a neurologist, a performance\u2010based test of function, quantitative computerized tremor analysis, the Hamilton Anxiety Rating Scale, and the depression module of the Structured Clinical Interview for DSM\u2010IV.<\/jats:p>\n                  <jats:p>Seventy\u2010six (85.4%) of 89 cases reported disability on \u22651 item on the disability questionnaire. In multivariate linear regression analyses, current major depression, Hamilton Anxiety Rating Scale score, age, and tremor severity were independently correlated with performance\u2010based test scores. Twenty\u2010seven (73.0%) of 37 community cases reported disability on \u22651 (mean = 8.4) item on the questionnaire, and 25 (67.6%) demonstrated moderate or greater difficulty on \u22651 (mean = 4.2) task in a performance\u2010based test.<\/jats:p>\n                  <jats:p>Depression, anxiety, and age, independent of the severity of tremor, were associated with greater functional disability in ET, so that these factors must be considered when assessing the impact of new treatments in ET. Among a group of community\u2010dwelling cases, approximately three\u2010quarters reported disability, suggesting that the number of individuals who might receive some benefit from advances in the treatment of ET is probably a great deal larger than previously thought. \u00a9 2001 Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.1184","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T17:15:54Z","timestamp":1030295754000},"page":"914-920","source":"Crossref","is-referenced-by-count":202,"title":["Correlates of functional disability in essential tremor"],"prefix":"10.1002","volume":"16","author":[{"given":"Elan D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Cote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin R.","family":"Schneier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth L.","family":"Pullman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198912000-00001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.10.1522"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.12.1982"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00870673"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.1001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130315"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130414"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199809)13:9<601::AID-GPS827>3.0.CO;2-B"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700001872"},{"issue":"144","key":"e_1_2_6_11_2","first-page":"1","article-title":"Essential tremor: a clinical and genetic population study","volume":"36","author":"Larsson T","year":"1960","journal-title":"Acta Psychiatrica Et Neurologica Scandinavica"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb03129.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(99)00028-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<516::AID-MDS1015>3.0.CO;2-J"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.7.841"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540360079019"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109681"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1351"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.12.1553"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.10.1861"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1968.tb02103.x"},{"issue":"1","key":"e_1_2_6_22_2","first-page":"179","article-title":"Modified mini\u2010mental state examination: validity and reliability","volume":"37","author":"Stern Y","year":"1987","journal-title":"Neurology"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_24_2","volume-title":"Structured Clinical Interview for DSM IV\u2014Patient Edition (SCID\u2010P)","author":"First M","year":"1995"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520210007009"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.1045"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1150"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130315"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.3.289"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.4.475"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199905)14:3<468::AID-MDS1013>3.0.CO;2-M"},{"key":"e_1_2_6_32_2","unstructured":"US Department of Census. 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