{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:10:56Z","timestamp":1763035856477,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,3,8]],"date-time":"2004-03-08T00:00:00Z","timestamp":1078704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fragile X\u2010associated tremor\/ataxia syndrome (FXTAS), a neurodegenerative disorder, was described recently among male carriers of expanded alleles (55\u2013200 CGG repeats; premutation range) of the fragile X mental retardation 1 (<jats:italic>FMR1<\/jats:italic>) gene. Major features of the syndrome include intention tremor, gait ataxia, and parkinsonism in men over 50 years of age. This disorder is believed to be relatively common, possibly affecting 1 in 3,000 men over the age of 50 years in the general population. This raises the possibility that some patients presenting with essential tremor (ET) may harbor expanded <jats:italic>FMR1<\/jats:italic> alleles. We screened 81 ET patients (40 males, 41 females) for expanded <jats:italic>FMR1<\/jats:italic> alleles to determine whether ET is associated with such alleles. None of the ET cases had the premutation genotype. CGG repeat sizes ranged from 5 to 47 repeats within this study population, suggesting that expanded <jats:italic>FMR1<\/jats:italic> alleles are uncommon among patients with ET. Screening of movement disorder patients with other clinical features of FXTAS (e.g., ataxia and parkinsonism) may be more likely to yield expanded <jats:italic>FMR1<\/jats:italic> alleles. \u00a9 2004 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20043","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T13:25:36Z","timestamp":1080221136000},"page":"930-933","source":"Crossref","is-referenced-by-count":43,"title":["Screen for expanded <i>FMR1<\/i> alleles in patients with essential tremor"],"prefix":"10.1002","volume":"19","author":[{"given":"Dolores","family":"Garcia Arocena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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