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The study was designed to detect a mean 30% reduction in composite tremor score, comparable to that of primidone or propranolol, which can be demonstrated with 30 or fewer subjects. Each treatment arm included baseline tremor assessments, a 4\u2010week medication titration, 2 weeks of stable dose, and treatment tremor assessments. Levetiracetam was titrated to 3,000 mg\/day or to a lower maximal tolerated dose. The median age was 72 years, with 28 years median tremor duration. There was no statistically significant difference in response between placebo and levetiracetam on any tremor rating scale or accelerometry measure. The 95% confidence interval for the true mean difference between placebo and levetiracetam treatments was +18.5 to \u221222.5%, which excludes the minimum 30% drop required to consider levetiracetam clinically effective to a degree comparable to primidone or propranolol. Whether levetiracetam has lesser\u2010degree antitremor efficacy was not addressed in this pilot study. \u00a9 2004 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20147","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T19:01:09Z","timestamp":1084474869000},"page":"1215-1221","source":"Crossref","is-referenced-by-count":49,"title":["Pilot efficacy and tolerability: A randomized, placebo\u2010controlled trial of levetiracetam for essential tremor"],"prefix":"10.1002","volume":"19","author":[{"given":"Adrian","family":"Handforth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredricka C.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00410-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00436-O"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)00105-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704141"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01884-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.24501.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2000.0504"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0689"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.858"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1684\/j.1950-6945.2000.tb00445.x","article-title":"Antimyoclonic effect of levetiracetam","volume":"2","author":"Genton P","year":"2000","journal-title":"Epiloptic Disord"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.6.1112"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10027"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00105-9"},{"key":"e_1_2_6_15_2","first-page":"271","volume-title":"Parkinson's disease and movement disorders","author":"Fahn SE","year":"1993"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110306"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.64"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.4.475"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.10.1494"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531692"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(84)80014-8"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.1045"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1986.tb04622.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198904000-00009"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.5.393"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(61)90060-1"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<678::AID-MDS1012>3.0.CO;2-0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199619060-00009"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.7.1019"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.20147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.20147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:33:17Z","timestamp":1760956397000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.20147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,13]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1002\/mds.20147"],"URL":"https:\/\/doi.org\/10.1002\/mds.20147","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,13]]}}}