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In a first experiment, participants lifted and held instrumented objects of different weight. In a second experiment, participants performed vertical point\u2010to\u2010point and continuous arm movements at different frequencies with a hand\u2010held object. In a third experiment, preparatory and reactive grip force responses to sudden load perturbations were analyzed when a weight was dropped into a hand\u2010held cup either by the subject or unexpectedly by the experimenter. Compared to the healthy subjects, GTS patients had increased grip forces relative to the load force in all tasks. Despite this finding, they adjusted the grip force to changes in load force (due to either a change in the mass lifted or accelerating the mass during continuous movements) in the same way as healthy subjects. The temporal coupling between grip and load force profiles was also similar in patients and healthy controls, and they displayed normal anticipation of impact forces when they dropped a weight into a hand\u2010held cup. We found no significant effect of medication on the performance of GTS patients, regardless of the task performed. These results are consistent with deficient sensory\u2013motor processing in Gilles de la Tourette syndrome. \u00a9 2004 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20309","type":"journal-article","created":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T19:01:14Z","timestamp":1095706874000},"page":"217-223","source":"Crossref","is-referenced-by-count":36,"title":["Grip force behavior in Gilles de la Tourette syndrome"],"prefix":"10.1002","volume":"20","author":[{"given":"Dennis A.","family":"Nowak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Topka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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