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We measured harmaline tremor in rats (10 mg\/kg s.c.) and mice (20 mg\/kg s.c.) with a load sensor under the cage floor and performed spectral analysis on 20\u2010minute epochs. The motion power over the tremor frequency bandwidth (8\u201312 Hz in rats; 10\u201316 Hz in mice) was divided by the motion power over the full motion frequency range (0\u201315 Hz in rats; 0\u201334 Hz in mice). The use of these measures greatly reduced data variability, permitting experiments with small sample sizes. Three drugs that suppress ET (propranolol, ethanol, and octanol) all significantly suppressed harmaline\u2010induced tremor. We propose that, with this methodology, harmaline\u2010induced tremor may be useful as a preclinical method to identify potential medications for ET. \u00a9 2004 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20331","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T17:16:28Z","timestamp":1102094188000},"page":"298-305","source":"Crossref","is-referenced-by-count":95,"title":["Harmaline\u2010induced tremor as a potential preclinical screening method for essential tremor medications"],"prefix":"10.1002","volume":"20","author":[{"given":"Fredricka C.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh","family":"Thu 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