{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:48:38Z","timestamp":1767016118083,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T00:00:00Z","timestamp":1102896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is considerable controversy regarding the relationship between essential tremor (ET) and Parkinson's disease (PD), especially when tremor is the dominant feature of PD or there is a family history of tremor. Reduced olfaction function is one of the initial signs of PD. In contrast, ET has relatively preserved olfaction. To infer whether the tremor\u2010dominant subgroup of PD is intrinsically different from mainstream PD, we tested olfaction using the University of Pennsylvania Smell Identification Test\u201040 (UPSIT) in this group and compared the findings with those of patients with non\u2013tremor\u2010dominant \u201cregular\u201d PD. We then evaluated predictors of reduced UPSIT scores within the tremor\u2010dominant group. Overall, olfaction did not differ between tremor\u2010dominant PD and regular PD; however, the subgroup of tremor\u2010dominant PD with a family history of tremor had less olfaction loss than those without a family history (<jats:italic>P<\/jats:italic> = 0.0007) or those with regular PD (<jats:italic>P<\/jats:italic> = 0.0350). Other clinical features of this tremor\u2010dominant PD with a family history of tremor group mostly resembled those without a family history. This finding suggests that patients with a family history of tremor may represent a different disease process even though, aside from differences in olfaction, they are clinically similar to other patients with tremor\u2010dominant parkinsonism. It additionally suggests phenotypic overlap between PD and ET. \u00a9 2004 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20365","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T20:55:33Z","timestamp":1105131333000},"page":"471-475","source":"Crossref","is-referenced-by-count":35,"title":["Olfaction testing in patients with tremor\u2010dominant Parkinson's disease: Is this a distinct condition?"],"prefix":"10.1002","volume":"20","author":[{"given":"William 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