{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:31:19Z","timestamp":1772011879265,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T00:00:00Z","timestamp":1105488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon\u2010\u03b3 (IFN\u2010\u03b3; T874A in intron 1), interferon\u2010\u03b3 receptor 2 (IFN\u2010\u03b3 R2; Gln64Arg), interleukin\u201010 (IL\u201010; G1082A in the promoter region), platelet\u2010activating factor acetylhydrolase (PAF\u2010AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM\u20101; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL\u201010 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A\u2010alleles (<jats:italic>P<\/jats:italic> = 0.0095; after Bonferroni correction, <jats:italic>P<\/jats:italic> = 0.048), resulting in a 5\u2010year delayed age of onset of the disease for individuals having two G\u2010alleles compared with individuals having two A\u2010alleles. The results indicate that the IL\u201010 G1082A SNP could possibly be related to the age of onset of PD. \u00a9 2005 Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.20378","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T19:48:25Z","timestamp":1105559305000},"page":"569-573","source":"Crossref","is-referenced-by-count":40,"title":["Investigation of genes coding for inflammatory components in Parkinson's 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